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      Isoenzymes of Lactate Dehydrogenase in Varicose Veins

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      Journal of Vascular Research

      S. Karger AG

      Lactate dehydrogenase fractions, Veins, Varices

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          Abstract

          The activity of lactate dehydrogenase and fractions of this enzyme has been estimated in human large saphenous veins. Typical varicosities were compared in composition with normal veins from the same patients. The total LDH activity was significantly decreased in typical varicosities. Varicose veins further differed from macroscopically normal veins by a lower content of aerobic fractions of LDH and a higher content of anaerobic fractions. These results suggest that there is a disturbance in metabolism of the smooth muscle of the venous wall in varicosities which would make the diseased wall more dependent on anaerobic glycolysis than normal tissue.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1975
          1975
          18 September 2008
          : 12
          : 5
          : 302-306
          Affiliations
          Centre for Research on Cardiovascular Diseases (Director: Prof. L. Hejhal), and Institute of Clinical and Experimental Medicine (Director: Prof. P. Málek), Prague
          Article
          158065 Blood Vessels 1975;12:302–306
          10.1159/000158065
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
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