5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Tryptophan pyrrole ring cleavage enzymes in placenta.

      Advances in experimental medicine and biology
      Animals, Base Sequence, Female, In Situ Hybridization, Indoleamine-Pyrrole 2,3,-Dioxygenase, Mice, Mice, Inbred ICR, Placenta, enzymology, Pregnancy, RNA, Messenger, genetics, metabolism, Reverse Transcriptase Polymerase Chain Reaction, Tryptophan, analogs & derivatives, pharmacology, Tryptophan Oxygenase

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Tryptophan pyrrole ring cleavage enzymes were assayed in pregnant uterus of mouse. The highest activity was observed at 6.5 days post-coitus (dpc) with a small activity shoulder at 9.5 to 12.5 dpc concepti and placenta. The highest peak at early concepti of 6.5 dpc was coincided with gene expression of tryptophan 2,3-dioxygenase (TDO). And the shoulder from 9.5 dpc was coincided with the expression of indoleamine 2,3-dioxygenase (IDO). These enzymes showed a different inhibitory behavior to a proper IDO inhibitor, 1-methyl tryptophan. In situ hybridization analysis revealed that TDO was expressed in the decidua of the early concepti. This is the first report of the extra hepatic TDO.

          Related collections

          Author and article information

          Comments

          Comment on this article