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      Clinical Importance of Endometrial Histology and Progesterone Level Assessment in Luteal-Phase Defect

      Hormone Research in Paediatrics

      S. Karger AG

      Progesterone, Luteal-phase defect, Endometrial biopsy

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          Abstract

          In order to clarify the relationship between endometrial histology and progesterone (P<sub>4</sub>), plasma P<sub>4</sub> and estradiol levels in the luteal phase were measured in 126 cases of unexplained infertility. Endometrial biopsies were performed in the midluteal period of menstrual cycles. Forty-three of the 126 cases showed retarded endometrium. Of these 43 cases, 23 exhibited three different types of abnormal P<sub>4</sub> secretion. Type A showed low P<sub>4</sub> levels throughout the luteal period. Type B showed low P<sub>4</sub> levels only in the early luteal period. Type C showed normal P<sub>4</sub> levels in the early luteal period followed by a prompt decline. These findings indicated that P<sub>4</sub> determination during the early, mid- and late luteal phases is necessary to assess P<sub>4 </sub>secretion. However, 20 of the 43 cases had normal P<sub>4</sub> levels through the entire luteal phase, demonstrating an insufficient response of the endometrium to P<sub>4</sub>. Consequently, histological examination of the endometrium is required to investigate the luteal phase defect.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5625-5
          978-3-318-01972-8
          1663-2818
          1663-2826
          1992
          1992
          03 December 2008
          : 37
          : Suppl 1
          : 53-58
          Affiliations
          Department of Obstetrics and Gynecology, School of Medicine, Jikei University, Tokyo, Japan
          Article
          182351 Horm Res 1992;37:53–58
          10.1159/000182351
          1427630
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          New Aspects of the Physiology and Pathology of the Luteal Phase

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