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      Osteoarthritis pathogenesis: a review of molecular mechanisms.

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          Abstract

          Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage matrix and development of OA are poorly understood and there are currently no effective interventions to decelerate the progression of OA or retard the irreversible degradation of cartilage except for total joint replacement surgery. In this paper, the important molecular mechanisms related to OA pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of OA will be provided.

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          Author and article information

          Journal
          Calcif. Tissue Int.
          Calcified tissue international
          1432-0827
          0171-967X
          Dec 2014
          : 95
          : 6
          Affiliations
          [1 ] Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, 312000, Zhejiang, China.
          Article
          NIHMS756501
          10.1007/s00223-014-9917-9
          4747051
          25311420
          6853e860-488d-49e3-bcd0-b9fb596a2c89
          History

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