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      The different roles of ER subtypes in cancer biology and therapy.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-1768
          1474-175X
          Jul 22 2011
          : 11
          : 8
          Affiliations
          [1 ] Center for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston 77204, Texas, USA.
          Article
          nrc3093
          10.1038/nrc3093
          21779010
          6866edd4-469a-4164-af6a-4dbca626edf2
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