On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction

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Abstract

An adhesive yet easily removable burn wound dressing represents a breakthrough in second-degree burn wound care. Current second-degree burn wound dressings absorb wound exudate, reduce bacterial infections, and maintain a moist environment for healing, but are surgically or mechanically debrided from the wound, causing additional trauma to the newly formed tissues. We have developed an on-demand dissolvable dendritic thioester hydrogel burn dressing for second-degree burn care. The hydrogel is composed of a lysine-based dendron and a PEG-based crosslinker, which are synthesized in high yields. The hydrogel burn dressing covers the wound and acts as a barrier to bacterial infection in an in vivo second-degree burn wound model. A unique feature of the hydrogel is its capability to be dissolved on-demand, via a thiol-thioester exchange reaction, allowing for a facile burn dressing removal. A hydrogel-based dressing for second-degree burn wounds has been synthesized and tested in vivo. It is composed of a dendritic macromonomer and a PEG crosslinker that form a hydrogel upon mixing. An on-demand and atraumatic hydrogel dissolution proceeds via thiol-thioester exchange reaction in presence of a cysteine methyl ester solution. <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/abaf5d47-b2b7-4f70-bdda-f1cce08d4244/PubMedCentral/image/nihms833482u1.jpg"/> </div>

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