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      “COVID-19 y estudios microbiológicos post mortem” Translated title: “COVID-19 and post-mortem microbiological studies”

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          Resumen

          En este artículo se revisan los aspectos microbiológicos de la infección COVID-19 y se presentan las recomendaciones sobre los análisis que deben realizarse en casos forenses. En primer lugar, se analizan las características taxonómicas del virus, su relación con la familia coronaviridae y su estructura genética. Se presentan brevemente las características clínicas y patológicas de la infección COVID-19 así como las coinfecciones que pueden asociarse a este virus. En el diagnóstico de laboratorio se describe la PCR, técnica de elección en la fase aguda de la infección; los estudios antigénicos y los serológicos. Finalmente se detallan los principales objetivos para los estudios microbiológicos en fallecidos en relación a la pandemia COVID-19 y se describen los principales análisis microbiológicos post- mórtem a realizar en fallecidos en el ámbito forense. Los estudios microbiológicos deben estar dirigidos tanto a la detección del SARS-CoV-2 como de las coinfecciones, que también podrían contribuir a la causa de muerte.

          Translated abstract

          We review the microbiological aspects of COVID-19 infection and present the microbiological studies that should be performed in forensic cases. We describe the taxonomic characteristics of the virus, its relationship with the coronaviridae family and its genetic structure. We briefly present the clinical and pathological characteristics of COVID-19 infection, as well as the co-infections that could be associated with this virus. In the laboratory, PCR is a first-choice technique in the acute phase of the infection, together with antigen and serological studies. Finally, we describe the main objectives of microbiological studies in the deceased in relation to the COVID-19 pandemic, as well as the main post-mortem microbiological analysis to be carried out in the medico-legal context. The microbiological analysis should aim to detect both SARS-CoV-2 and coinfections, which may also contribute to the cause of death.

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          Author and article information

          Contributors
          Journal
          Revista Española de Medicina Legal
          Published by Elsevier España, S.L.U. on behalf of Asociación Nacional de Médicos Forenses.
          0377-4732
          2173-917X
          15 May 2020
          15 May 2020
          Affiliations
          [1 ]Laboratorio de Microbiología, Servicio de Biología, Instituto Nacional de Toxicología y Ciencias Forenses, Las Rozas de Madrid, Madrid, Spain
          [2 ]Laboratorio de Referencia de Gripe y Virus Respiratorios. Centro Nacional de Microbiología. Instituto de Salud Carlos III, España
          [3 ]Servicio de Microbiología. Hospital Clínico San Carlos, Madrid, España
          [4 ]Servicio de Microbiología Hospital Nuestra Señora del Prado, Talavera de la Reina, Toledo, España
          [5 ]Histopathology Department, Sheffield Children’s Hospital NHS FT, Sheffield, UK
          [6 ]Department of Metabolism and Oncology, University of Sheffield, Sheffield, UK
          [7 ]Servicio de Microbiología. Hospital Universitario Peset, Valencia, España
          Author notes
          Article
          S0377-4732(20)30030-4
          10.1016/j.reml.2020.05.007
          7225694
          6872a01c-9a70-4b3e-a302-c25e86f97e02
          © 2020 Published by Elsevier España, S.L.U. on behalf of Asociación Nacional de Médicos Forenses.

          Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

          History
          : 10 May 2020
          : 11 May 2020
          Categories
          Article

          sars-cov-2,covid-19,microbiología forense,microbiología post-mórtem

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