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      Orbital Tumor in Acute Myeloid Leukemia Associated with Karyotype 46,XX,t(8;21)(q22;q22): A Case Report


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          Orbital tumor formation in acute myeloid leukemia (AML) is rare as an initial symptom. Furthermore, orbital granulocytic sarcoma (myeloid sarcoma) in pediatric patients is uncommon. We describe a 5-year-old Japanese girl with a left orbital mass as an initial symptom of AML, the mass revealed by computed tomography. Periperal blood and bone marrow pictures and a chromosomal analysis disclosing 46,XX,t(8;21)(q22;q22) showed AML (M2 according to the French-American-British classification). She was treated with antileukemic chemotherapy systemically. Three weeks after the initiation of chemotherapy, the orbital tumor regressed markedly. AML as an initial symptom of the orbital mass should be fully considered in a differential diagnosis, even in the absence of typical leukemic symptoms, and chromosomal analysis and immunophenotypical analysis may explain the pathogenesis of the extramedullary leukemic tumor.

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          Author and article information

          S. Karger AG
          June 1998
          19 March 1998
          : 212
          : 3
          : 202-205
          Departments of aOphthalmology and bPediatrics, Nagasaki University School of Medicine, Nagasaki, Japan
          27279 Ophthalmologica 1998;212:202–205
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 6, References: 27, Pages: 4
          Case Report · Description de cas · Fallbericht

          Vision sciences,Ophthalmology & Optometry,Pathology
          Orbital tumor,Acute myeloid leukemia,Chromosomal translocation t(8;21)


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