Further new eunicellin-based diterpenoids from the Guangxi Weizhou soft coral Cladiella krempfi.

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Abstract

Three new polyoxygenated diterpenes (1, 3 and 4) of eunicellin-type, namely, 8-n-butyryl-litophynol A, 6-keto-litophynol B and 6-epi-litophynol B, respectively, together with two related known ones (2 and 5), were isolated from the soft coral Cladiella krempfi collected off the Weizhou island, Guangxi Zhuang Autonomous Region, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical correlation. In bioassay, all the new compounds displayed moderate anti-inflammatory effects.

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Journal

Journal ID (iso-abbrev): Fitoterapia

Title: Fitoterapia

Publisher: Elsevier BV

ISSN (Electronic): 1873-6971

ISSN (Print): 0367-326X

Publication date (Electronic): Nov 2018

Volume: 131

Affiliations

[1 ] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

[2 ] Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.

[3 ] College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

[4 ] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: ywguo@simm.ac.cn.

Article

Publisher Item ID: S0367-326X(18)31519-3

DOI: 10.1016/j.fitote.2018.10.012

PubMed ID: 30336194

SO-VID: 68a3e6bc-bee2-43e5-8a17-1e0c1ce03519

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