Distribution of neuropeptides in the limbic system of the rat: The amygdaloid complex

Crow, T.J.; Polak, J.M.; Roberts, G.W.; Woodhams, P.L.

doi:10.1016/0306-4522(82)90156-7

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Distribution of neuropeptides in the limbic system of the rat: The amygdaloid complex

Author(s): G.W. Roberts , P.L. Woodhams , J.M. Polak , T.J. Crow

Publication date Created: January 1982

Publication date (Print): January 1982

Journal: Neuroscience

Publisher: Elsevier BV

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Identification of two related pentapeptides from the brain with potent opiate agonist activity.

J. Hughes, T W Smith, H Kosterlitz … (1975)

Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.