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      CDK inhibitors: cell cycle regulators and beyond.

      1 , ,
      Developmental cell
      Elsevier BV

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          Abstract

          First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and p57Kip2 have emerged as multifaceted proteins with functions beyond cell cycle regulation. In addition to regulating the cell cycle, Cip/Kip proteins play important roles in apoptosis, transcriptional regulation, cell fate determination, cell migration and cytoskeletal dynamics. A complex phosphorylation network modulates Cip/Kip protein functions by altering their subcellular localization, protein-protein interactions, and stability. These functions are essential for the maintenance of normal cell and tissue homeostasis, in processes ranging from embryonic development to tumor suppression.

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          Author and article information

          Journal
          Dev Cell
          Developmental cell
          Elsevier BV
          1534-5807
          1534-5807
          Feb 2008
          : 14
          : 2
          Affiliations
          [1 ] Université de Toulouse - LBCMCP and CNRS - UMR5088, Toulouse, France.
          Article
          S1534-5807(08)00041-5
          10.1016/j.devcel.2008.01.013
          18267085
          68b4c679-fc4d-4f9f-a95f-ea40c5ed37de
          History

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