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      Investigation of the effect of dietary intake of omega‐3 polyunsaturated fatty acids on trauma‐induced white matter injury with quantitative diffusion MRI in mice

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          Abstract

          Previous studies suggest that long‐term supplementation and dietary intake of omega‐3 polyunsaturated fatty acids (PUFAs) may have neuroprotective effects following brain injury. The objective of this study was to investigate potential neuroprotective effects of omega‐3 PUFAs on white matter following closed‐head trauma. The closed‐head injury model of engineered rotational acceleration (CHIMERA) produces a reproducible injury in the optic tract and brachium of the superior colliculus in mice. Damage is detectable using diffusion tensor imaging (DTI) metrics, particularly fractional anisotropy (FA), with sensitivity comparable to histology. We acquired in vivo ( n = 38) and ex vivo ( n = 41) DTI data in mice divided into sham and CHIMERA groups with two dietary groups: one deficient in omega‐3 PUFAs and one adequate in omega‐3 PUFAs. We examined injury effects (reduction in FA) and neuroprotection (FA reduction modulated by diet) in the optic tract and brachium. We verified that diet did not affect FA in sham animals. In injured animals, we found significantly reduced FA in the optic tract and brachium (~10% reduction, p < 0.001), and Bayes factor analysis showed strong evidence to reject the null hypothesis. However, Bayes factor analysis showed substantial evidence to accept the null hypothesis of no diet‐related FA differences in injured animals in the in vivo and ex vivo samples. Our results indicate no neuroprotective effect from adequate dietary omega‐3 PUFA intake on white matter damage following traumatic brain injury. Since damage from CHIMERA mainly affects white matter, our results do not necessarily contradict previous findings showing omega‐3 PUFA‐mediated neuroprotection in gray matter.

          Abstract

          We investigated potential neuroprotective effects of dietary omega‐3 polyunsaturated fatty acids (PUFAs) on white matter damage following closed‐head injury in mice. While injured animals exhibited reduced fractional anisotropy (FA) in the optic tract and brachium compared to the uninjured animals, there was no evidence of neuroprotection from dietary omega‐3 PUFAs.

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          Most cited references52

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          FSL.

          FSL (the FMRIB Software Library) is a comprehensive library of analysis tools for functional, structural and diffusion MRI brain imaging data, written mainly by members of the Analysis Group, FMRIB, Oxford. For this NeuroImage special issue on "20 years of fMRI" we have been asked to write about the history, developments and current status of FSL. We also include some descriptions of parts of FSL that are not well covered in the existing literature. We hope that some of this content might be of interest to users of FSL, and also maybe to new research groups considering creating, releasing and supporting new software packages for brain image analysis. Copyright © 2011 Elsevier Inc. All rights reserved.
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            Advances in functional and structural MR image analysis and implementation as FSL.

            The techniques available for the interrogation and analysis of neuroimaging data have a large influence in determining the flexibility, sensitivity, and scope of neuroimaging experiments. The development of such methodologies has allowed investigators to address scientific questions that could not previously be answered and, as such, has become an important research area in its own right. In this paper, we present a review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB). This research has focussed on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data. The majority of the research laid out in this paper has been implemented as freely available software tools within FMRIB's Software Library (FSL).
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              Bayes Factors

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                Author and article information

                Contributors
                laura.reyes@nih.gov
                Journal
                J Neurosci Res
                J Neurosci Res
                10.1002/(ISSN)1097-4547
                JNR
                Journal of Neuroscience Research
                John Wiley and Sons Inc. (Hoboken )
                0360-4012
                1097-4547
                25 August 2020
                November 2020
                : 98
                : 11 ( doiID: 10.1002/jnr.v98.11 )
                : 2232-2244
                Affiliations
                [ 1 ] Quantitative Medical Imaging Section National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD USA
                [ 2 ] Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda MD USA
                [ 3 ] Center for Neuroscience and Regenerative Medicine, Uniformed Services University Bethesda MD USA
                [ 4 ] Laboratory of Molecular Signaling National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA
                [ 5 ] Georgia Cancer Center Augusta University Augusta GA USA
                [ 6 ] Department of Radiology and Radiological Sciences Uniformed Services University Bethesda MD USA
                Author notes
                [*] [* ] Correspondence

                Laura D. Reyes, Quantitative Medical Imaging Section, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Dr, Building 13 Room 3W43, Bethesda, MD 20852, USA.

                Email: laura.reyes@ 123456nih.gov

                Author information
                https://orcid.org/0000-0002-0404-1817
                Article
                JNR24705
                10.1002/jnr.24705
                7589213
                32840025
                68b6a022-b850-458f-865d-b2d4e7ed9c06
                © 2020 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 04 March 2020
                : 09 July 2020
                : 11 July 2020
                Page count
                Figures: 4, Tables: 5, Pages: 13, Words: 10376
                Funding
                Funded by: Henry M. Jackson Foundation , open-funder-registry 10.13039/100003896;
                Award ID: CNRM 307513‐3.01‐60855
                Categories
                Research Article
                Research Articles
                Custom metadata
                2.0
                November 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.3 mode:remove_FC converted:27.10.2020

                Neurosciences
                closed‐head injury,diffusion tensor imaging,mouse,mri,omega‐3 fatty acids,traumatic brain injury

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