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      An Experimental Model for Measuring Intestinal Permeability

      research-article
      , ,
      Digestion
      S. Karger AG
      Intestinal permeability, Cytotoxic treatment, Bile acids, Chelating agent, Mannitol, Phenol red, Inulin, PVP

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          Abstract

          In the nonanesthetized rat, the jejunal permeability to four simultaneously administered molecules, mannitol, phenol red, inulin and PVP, was measured by analyzing blood, serum, urine and duodenal fluid for these compounds. Of the molecules which had entered the body, approximately 50% were found in the urine, another 50% in the extracellular space and only about 1 % were excreted into the duodenal juice. The intracellular content of the molecules is not accounted for in these numbers. The rate of permeation decreased with increasing molecular weight of the substances. EDTA (25 mmol/l) and deoxycholate (5 mmol/l) increased the jejunal permeability for these molecules but not for mannitol. The alterations in mucosal cell turnover and morphology induced by hydroxyurea did not change jejunal permeability for mannitol and phenol red at any time. 24 and 48 h following hydroxyurea, jejunal permeability for inulin and PVP was decreased.

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          Author and article information

          Journal
          DIG
          Digestion
          10.1159/issn.0012-2823
          Digestion
          S. Karger AG
          0012-2823
          1421-9867
          1983
          1983
          28 January 2009
          : 26
          : 1
          : 24-32
          Affiliations
          Department of Clinical Chemistry, University of Marburg, and Central Laboratory for Isotope Application, University of Ulm, FRG
          Article
          198865 Digestion 1983;26:24–32
          10.1159/000198865
          6404682
          68b983c9-c511-44f1-a4c9-888eabb126e8
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 21 June 1982
          Page count
          Pages: 9
          Categories
          Original Paper

          Oncology & Radiotherapy,Gastroenterology & Hepatology,Surgery,Nutrition & Dietetics,Internal medicine
          Cytotoxic treatment,PVP,Intestinal permeability,Bile acids,Chelating agent,Mannitol,Phenol red,Inulin

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