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      Transperitoneal Absorption and Kinetics of Chromium in the Continuous Ambulatory Peritoneal Dialysis Patient – An Experimental and Mathematical Analysis

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          Abstract

          The functional model of Cr kinetics and metabolism described by Lim et al. [Am J Physiol 1983;224:R445-R454] for healthy people was adapted to the specific situation of the continuous ambulatory peritoneal dialysis (CAPD) patient. For this purpose 3 CAPD patients were submitted to an acute <sup>51</sup>Cr-labelled dialysis dwell of 6 h. The rate of uptake of Cr in the plasma appeared to be equal to its disappearance rate from the peritoneal fluid. The plasma levels increased to a constant value in the first 2 h after the start of the dialysis session. The amount of Cr cumulatively excreted in the urine over the follow-up period of 10-12 days was 10-15 % of the amount absorbed during the acute dwell. The experimental pharmacokinetic data were in close agreement with the values predicted by the modified functional model for Cr(III) kinetics and metabolism. According to this model, the effect of long-term CAPD treatment (10 years) should result in an accumulation of Cr with a factor of 100 in those organs, especially liver and spleen, known to have a slow exchange of Cr with the central plasma compartment. This predicted and dramatic increase was in close agreement with the Cr concentrations found in liver tissue of 3 patients who died after a variable time on CAPD.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1996
          1996
          18 December 2008
          : 72
          : 2
          : 163-170
          Affiliations
          aLaboratory of Analytical Chemistry, Universiteit Gent, and bRenal Division, University Hospital, Gent, Belgium
          Article
          188836 Nephron 1996;72:163–170
          10.1159/000188836
          8684521
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Peritoneal kinetics, Peritoneal dialysis, Chromium, Trace metals

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