9
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      Are you tired of sifting through news that doesn't interest you?
      Personalize your Karger newsletter today and get only the news that matters to you!

      Sign up

      • Record: found
      • Abstract: found
      • Article: found

      Combined Pharmacologic Therapy in a Rabbit Model of Proliferative Vitreoretinopathy (PVR)

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose: This study was designed to evaluate the efficacy of a combined treatment, previously used to prevent fibrosis after glaucoma surgery, to inhibit an experimental model of proliferative vitreoretinopathy (PVR). Methods: Two groups of albino rabbits were used. In the control group (group 1, n = 14), experimental PVR was induced using vitrectomy, retinotomies, cryotherapy and intraocular injection of platelet-rich plasma. In the experimental group (group 2, n = 15), after PVR was induced, the following treatment was administered for 4 weeks: systemic methylprednisolone, sodium diclofenac and colchicine combined with topical atropine 1%, adrenaline 10% and dexamethasone phosphate 0.1%. Follow- up consisted of fundus examination for 4 weeks. Results were classified according to Fastenberg’s classification. Only retinal detachments were considered to compare the two groups. Nonparametric test was used. Results: Retinal detachments were observed in 85.7% of group 1 and 33.3% of group 2 at the end of the follow-up (p < 0.01). No major systemic complications were observed. Conclusions: Combined therapy seems to be useful for treating experimental PVR.

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: not found

          The role of retinotomy in an experimental rabbit model of proliferative vitreoretinopathy.

          To create a model of proliferative vitreoretinopathy (PVR) using retinotomy with vitrectomy, cryotherapy, and platelet-rich plasma (PRP) injection, which more closely resembles the human pathophysiologic condition.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Antiproliferative effect of retinoic acid in 1% sodium hyaluronate in an animal model of PVR

              Bookmark

              Author and article information

              Journal
              ORE
              Ophthalmic Res
              10.1159/issn.0030-3747
              Ophthalmic Research
              S. Karger AG
              0030-3747
              1423-0259
              2000
              February 2000
              04 February 2000
              : 32
              : 1
              : 25-29
              Affiliations
              aVitreoretinal Group and bOcular Pharmacology Laboratory, Instituto Universitario de Oftalmobiología Aplicada, (IOBA), Universidad de Valladolid, Spain
              Article
              55583 Ophthalmic Res 2000;32:25–29
              10.1159/000055583
              10657752
              68bf46cf-05d6-49b4-bcea-23c5ade5c08c
              © 2000 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              History
              Page count
              Tables: 3, References: 33, Pages: 5
              Categories
              Original Paper

              Vision sciences,Ophthalmology & Optometry,Pathology
              Proliferative vitreoretinopathy,Experimental model,Prophylactic treatment

              Comments

              Comment on this article