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      Combined Pharmacologic Therapy in a Rabbit Model of Proliferative Vitreoretinopathy (PVR)


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          Purpose: This study was designed to evaluate the efficacy of a combined treatment, previously used to prevent fibrosis after glaucoma surgery, to inhibit an experimental model of proliferative vitreoretinopathy (PVR). Methods: Two groups of albino rabbits were used. In the control group (group 1, n = 14), experimental PVR was induced using vitrectomy, retinotomies, cryotherapy and intraocular injection of platelet-rich plasma. In the experimental group (group 2, n = 15), after PVR was induced, the following treatment was administered for 4 weeks: systemic methylprednisolone, sodium diclofenac and colchicine combined with topical atropine 1%, adrenaline 10% and dexamethasone phosphate 0.1%. Follow- up consisted of fundus examination for 4 weeks. Results were classified according to Fastenberg’s classification. Only retinal detachments were considered to compare the two groups. Nonparametric test was used. Results: Retinal detachments were observed in 85.7% of group 1 and 33.3% of group 2 at the end of the follow-up (p < 0.01). No major systemic complications were observed. Conclusions: Combined therapy seems to be useful for treating experimental PVR.

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          Most cited references2

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          • Abstract: found
          • Article: not found

          The role of retinotomy in an experimental rabbit model of proliferative vitreoretinopathy.

          To create a model of proliferative vitreoretinopathy (PVR) using retinotomy with vitrectomy, cryotherapy, and platelet-rich plasma (PRP) injection, which more closely resembles the human pathophysiologic condition.
            • Record: found
            • Abstract: not found
            • Article: not found

            Antiproliferative effect of retinoic acid in 1% sodium hyaluronate in an animal model of PVR


              Author and article information

              Ophthalmic Res
              Ophthalmic Research
              S. Karger AG
              February 2000
              04 February 2000
              : 32
              : 1
              : 25-29
              aVitreoretinal Group and bOcular Pharmacology Laboratory, Instituto Universitario de Oftalmobiología Aplicada, (IOBA), Universidad de Valladolid, Spain
              55583 Ophthalmic Res 2000;32:25–29
              © 2000 S. Karger AG, Basel

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              Page count
              Tables: 3, References: 33, Pages: 5
              Original Paper

              Vision sciences,Ophthalmology & Optometry,Pathology
              Proliferative vitreoretinopathy,Experimental model,Prophylactic treatment


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