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      Serum Leptin in Short Children Born Small for Gestational Age: Dose-Dependent Effect of Growth Hormone Treatment

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          Objective: To study the effects of different regimens of growth hormone (GH) treatment on serum leptin levels in 78 short prepubertal children born small for gestational age (SGA). Methods: The children were originally included in two independent multicenter trials, one in Belgium and one in the Nordic countries. SGA children were randomized either to remain untreated or to be treated with GH at a daily dose of 0.1, 0.2 or 0.3 IU/kg for 2 years. Thereafter, treatment was continued for another 2 years in the Nordic children, whereas it was discontinued in the Belgian children. Results: In the GH treatment groups, a significant dose-dependent decrease in leptin levels was found during the first year of therapy, with a mean decrease of 13, 23 and 32% in the groups receiving GH at 0.1, 0.2 and 0.3 IU/kg, respectively. When high-dose treatment was interrupted, serum leptin increased within 1 year to pretreatment levels. Conclusion: Serum leptin levels in short children born SGA are transiently reduced by GH treatment in a dose-dependent fashion. The most pronounced changes in serum leptin were documented within the first year after initiation and withdrawal of high-dose GH treatment.

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          Most cited references 6

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          Design and synthesis of multi-haem proteins.

          A water-soluble, 62-residue, di-alpha-helical peptide has been synthesized which accommodates two bis-histidyl haem groups. The peptide assembles into a four-helix dimer with 2-fold symmetry and four parallel haems that closely resemble native haems in their spectral and electrochemical properties, including haem-haem redox interaction. This protein is an essential intermediate in the synthesis of molecular 'maquettes', a novel class of simplified versions of the metalloproteins involved in redox catalysis and in energy conversion in respiratory and photosynthetic electron transfer.
            • Record: found
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            Growth Hormone Treatment in Children with Short Stature Born Small for Gestational Age: 5-Year Results of a Randomized, Double-Blind, Dose-Response Trial

             T. Sas (1999)
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              Spontaneous 24-hour growth hormone profiles in prepubertal small for gestational age children


                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                21 April 2001
                : 54
                : 3
                : 120-125
                aInternational Pediatric Growth Research Center, Department of Pediatrics, University of Göteborg, Göteborg, Sweden; bPediatric Endocrinology Unit, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil; cDepartment of Pediatrics, University of Leuven, Leuven, Belgium
                53244 Horm Res 2000;54:120–125
                © 2001 S. Karger AG, Basel

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                Page count
                Figures: 2, Tables: 1, References: 33, Pages: 6
                Original Paper


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