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      Virtual reality device training for extracorporeal membrane oxygenation

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          Abstract

          Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with terminal respiratory failure. In the current worldwide surge of critically ill patients with novel coronavirus disease (COVID-19), ECMO demand for the sickest of them is unprecedentedly high and management is very complex [1]. Highly trained healthcare personnel is essential to safely prime, implant, and operate ECMO devices [2]. Acquisition of such complex skillsets has always been difficult—especially for smaller hospitals with lower ECMO case counts [3]. During the pandemic, traditional face-to-face instructor-led training is additionally complicated by social distancing measures. Alternative and complementary ways of delivering high-quality training are thus desirable to increase personnel resources for ECMO services. Virtual reality (VR) simulators are emerging as next-generation options in digital health to complement traditional training: VR training is largely independent of resources, location, and person-to-person contact; it integrates both teaching theory and practical application and allows unlimited repetition. Our research collaboration currently develops a prototype for VR training on an ECMO device (Fig. 1a): using a VR headset with controllers (Fig. 1b), trainees are immersed in a digital VR environment with a Getinge Cardiohelp® ECMO device (Fig. 1c+d). The virtual device is responsive to manual user input by movement of the body, head, and hands in the virtual space. A digital coach leads the trainee through a multi-layered didactic digital teaching program: beginners go through step-by-step video instructions and manually imitate each step on the ECMO device (Video 1); experts must perform tasks without any support (Video 2). Training includes sessions of the priming procedure of the device for use (Fig. 1c and Video 1) and configuring its program options (Fig. 1d and Video 2), each a complex sequence of single steps requiring specialized knowledge and manual skillsets. This VR prototype is ready to be evaluated for the ECMO priming procedure. It may be expanded to further content in the future, e.g., device troubleshooting or implantation. We are looking forward to reporting results of this innovative technology soon. Fig. 1 Virtual reality setup and Getinge Cardiohelp® ECMO training environment. Schematic drawing (a) and real-world shot (b) of a virtual reality setup, with scenes from the VR environment of priming (c) and controlling (d) the ECMO device Virtual reality device training for extracorporeal membrane oxygenation promises to be a very valuable tool for health care personnel training—both during the pandemic and beyond. Supplementary information Additional file 1: Video 1. Priming the device, beginner mode: Step-by-step instruction and manual repetition in Virtual Reality. Additional file 2: Video 2. Controlling the device, expert mode: Configuring device options in Virtual Reality.

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          Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases

          Summary WHO interim guidelines recommend offering extracorporeal membrane oxygenation (ECMO) to eligible patients with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). The number of patients with COVID-19 infection who might develop severe ARDS that is refractory to maximal medical management and require this level of support is currently unknown. Available evidence from similar patient populations suggests that carefully selected patients with severe ARDS who do not benefit from conventional treatment might be successfully supported with venovenous ECMO. The need for ECMO is relatively low and its use is mostly restricted to specialised centres globally. Providing complex therapies such as ECMO during outbreaks of emerging infectious diseases has unique challenges. Careful planning, judicious resource allocation, and training of personnel to provide complex therapeutic interventions while adhering to strict infection control measures are all crucial components of an ECMO action plan. ECMO can be initiated in specialist centres, or patients can receive ECMO during transportation from a centre that is not specialised for this procedure to an expert ECMO centre. Ensuring that systems enable safe and coordinated movement of critically ill patients, staff, and equipment is important to improve ECMO access. ECMO preparedness for the COVID-19 pandemic is important in view of the high transmission rate of the virus and respiratory-related mortality.
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            COVID-19 and ECMO: the interplay between coagulation and inflammation—a narrative review

            Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presently become a rapidly spreading and devastating global pandemic. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. While still little is known on the true efficacy of ECMO in this setting, the natural resemblance of seasonal influenza’s characteristics with respect to acute onset, initial symptoms, and some complications prompt to ECMO implantation in most severe, pulmonary decompensated patients. The present review summarizes the evidence on ECMO management of severe ARDS in light of recent COVID-19 pandemic, at the same time focusing on differences and similarities between SARS-CoV-2 and ECMO in terms of hematological and inflammatory interplay when these two settings merge.
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              ECMO-treatment in patients with acute lung failure, cardiogenic, and septic shock: mortality and ECMO-learning curve over a 6-year period

              Background Based on promising results over the past 10 years, the method of extracorporeal membrane oxygenation (ECMO) has developed from being used as a ‘rescue therapy’ to become an accepted treatment option for patients with acute lung failure (ARDS). Subsequently, the indication was extended also to patients suffering from cardiogenic and septic shock. Our aim was to evaluate hospital mortality and associated prognostic variables in patients with lung failure, cardiogenic, and septic shock undergoing ECMO. Furthermore, a cumulative sum (CUSUM) analysis was used to assess the learning curve of ECMO-treatment in our department. Methods We retrospectively analysed the data of 131 patients undergoing ECMO treatment in the intensive care unit of the Asklepios Hospital of Langen over the time period from April 2011 to July 2016. We categorised the patients into three groups: lung failure (n = 54); cardiogenic shock (n = 58); and septic shock (n = 19). The primary outcome variable was hospital mortality along with identification of prognostic variables on mortality before initiating ECMO using logistic regression. Second outcome variable was the learning curve of our department in patients with ECMO. Results 6-year hospital mortality was 54% in patients with lung failure, 59% in patients with cardiogenic shock, and 58% in patients with septic shock. The CUSUM analysis revealed a typical learning curve with a point of inflection in the year 2014. Patients treated before 2014 had a worse outcome (p = 0.04 whole cohort; p = 0.03 for lung failure). Furthermore, less than 20 treatments per year respectively treatment before 2014 were associated negatively with hospital mortality of lung failure patients showing an odds ratio of 4.04, as well as in the entire cohort with an odds ratio of 3.19. Conclusion For the first time, a steep ECMO-learning curve using the CUSUM tool has been described. Obviously, the experience with ECMO has to be taken into account when defining the role of ECMO in ARDS, cardiogenic, and septic shock.
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                Author and article information

                Contributors
                georg.wolff@med.uni-duesseldorf.de
                Journal
                Crit Care
                Critical Care
                BioMed Central (London )
                1364-8535
                1466-609X
                2 July 2020
                2 July 2020
                2020
                : 24
                : 390
                Affiliations
                [1 ]GRID grid.411327.2, ISNI 0000 0001 2176 9917, Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Medical Faculty, , Heinrich-Heine University, ; Moorenstr. 5, 40225 Düsseldorf, Germany
                [2 ]Getinge Group, Maquet GmbH, Kehlerstr. 31, 76437 Rastatt, Germany
                [3 ]Weltenmacher GmbH, Binterimstraße 8, 40223 Düsseldorf, Germany
                Author information
                http://orcid.org/0000-0002-1734-6177
                Article
                3095
                10.1186/s13054-020-03095-y
                7331115
                32616025
                68c4ec6d-a044-420f-9bdf-09141416ae47
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 6 June 2020
                : 15 June 2020
                Funding
                Funded by: Getinge
                Categories
                Letter
                Custom metadata
                © The Author(s) 2020

                Emergency medicine & Trauma
                virtual reality,ecmo,cardiohelp,vr,priming
                Emergency medicine & Trauma
                virtual reality, ecmo, cardiohelp, vr, priming

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