- Record: found
- Abstract: found
- Article: found
Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease ☆
review-article
23 May 2013
Akt, Protein kinase B,
AR, Aldose reductase,
ARE, Antioxidant response element,
AP-1, Activator protein-1,
ATF6, Activating transcription factor 6,
BH4, Tetrahydrobiopterin,
BAEC, Bovine aortic endothelial cells,
BLMVEC, Bovine lung microvascular vein endothelial cells,
BPAEC, Bovine pulmonary arterial endothelial cells,
BTB, Broad complex Tramtrack and Bric–brac domain,
CHOP, C/EBP-homologous protein,
CREB, cAMP response element-binding protein,
EGFR, Epidermal growth factor receptor,
elF2α, Eukaryotic translation initiation factor 2α,
Elk1, ETS domain-containing protein,
eNOS, Endothelial nitric oxide synthase,
EpRE, Electrophile response element,
ER, Endoplasmic reticulum,
ERAD, Endoplasmic reticulum assisted degradation,
ERK1/2, Extracellular signal-regulated kinase 1/2,
FAK, Focal adhesion kinase,
FAP, Familial amyloidotic polyneuropathy,
GCLC, Glutamate cysteine ligase catalytic subunit,
GCLM, Glutamate cysteine ligase modifier subunit,
GS-DHN, Glutathionyl-1,4 dihydroxynonene,
GSH, Glutathione,
GS-HNE, HNE-conjugates,
GST, Glutathione-S-transferase,
GTPCH, Guanosine triphosphate cyclohydrolase I,
HASMC, Human aortic smooth muscle cells,
HCSMC, Human coronary smooth muscle cells,
HERP, Homocysteine inducible ER protein,
HMEC, Human microvascular endothelial cells,
HO-1, Heme oxygenase-1,
HNE, 4-hydroxynonenal,
Hsp-70/72/90, Heat shock proteins-70/ -72/ -90,
HUVEC, Human umbilical vein endothelial cells,
iNOS, Inducible nitric oxide synthase,
IRE1, Inositol requiring enzyme 1 IRE1,
IVR, Central intervening region,
JNK, c-jun N-terminal kinase,
Keap1, Kelch-like ECH-associated protein 1,
MASMC, Mouse aortic smooth muscle cells,
MEK1/2, Mitogen activated protein kinase kinase 1/2,
MMP-1/2, Matrix metalloproteinase-1/ -2,
MPEC, Mouse pancreatic islet endothelial cells,
NAC, N-acetylcysteine,
NFκB, Nuclear factor kappa B,
NO, Nitric oxide,
NQO1, NAD(P)H quinone oxidoreductase,
Nrf2, Nuclear factor-E2-related factor 2,
oxLDL, Oxidized low density lipoprotein,
PCEC, Porcine cerebral endothelial cells,
PDGF, Platelet-derived growth factor,
PDI, Protein disulfide isomerases,
PERK, Protein kinase-like endoplasmic reticulum kinase,
15d-PGJ2, 15-deoxy-Delta (12,14) prostaglandin-J2,
PKC, Protein kinase C,
PUFAs, Polyunsaturated fatty acids,
RASMC, Rat aortic smooth muscle cells,
ROS, Reactive oxygen species,
RVSMC, Rat vascular smooth muscle cells,
SMC, Smooth muscle cell,
tBHP, Tert-butylhydroperoxide,
TKR, Tyrosine kinase receptor,
UPR, Unfolded protein response,
xCT, cystine/glutamate amino acid transporter,
4-hydroxynonenal,
Vascular biology,
Endothelial cells,
Vascular smooth muscle cells,
Redox signaling,
Nrf2
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within the vasculature is dependent not only on the rate of lipid peroxidation and HNE synthesis but also on the removal of HNE adducts by phase II metabolic pathways such as glutathione- S-transferases. Depending on its relative concentration, HNE can induce a range of hormetic effects in vascular endothelial and smooth muscle cells, including kinase activation, proliferation, induction of phase II enzymes and in high doses inactivation of enzymatic processes and apoptosis. HNE also plays an important role in the pathogenesis of vascular diseases such as atherosclerosis, diabetes, neurodegenerative disorders and in utero diseases such as pre-eclampsia. This review examines the known production, metabolism and consequences of HNE synthesis within vascular endothelial and smooth muscle cells, highlighting alterations in mitochondrial and endoplasmic reticulum function and their association with various vascular pathologies.
Highlights
Related collections
Most cited references154
- Record: found
- Abstract: found
- Article: not found
Endoplasmic reticulum stress signaling in disease.
Stefan Marciniak, David Ron (2006)
- Record: found
- Abstract: found
- Article: not found
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress.
Sara Cullinan, J. Diehl (2004)
- Record: found
- Abstract: found
- Article: not found
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Benbo Song, Donalyn Scheuner, David Ron … (2008)
Author and article information
akt, protein kinase b,ar, aldose reductase,are, antioxidant response element,ap-1, activator protein-1,atf6, activating transcription factor 6,bh4, tetrahydrobiopterin,baec, bovine aortic endothelial cells,blmvec, bovine lung microvascular vein endothelial cells,bpaec, bovine pulmonary arterial endothelial cells,btb, broad complex tramtrack and bric–brac domain,chop, c/ebp-homologous protein,creb, camp response element-binding protein,egfr, epidermal growth factor receptor,elf2α, eukaryotic translation initiation factor 2α,elk1, ets domain-containing protein,enos, endothelial nitric oxide synthase,epre, electrophile response element,er, endoplasmic reticulum,erad, endoplasmic reticulum assisted degradation,erk1/2, extracellular signal-regulated kinase 1/2,fak, focal adhesion kinase,fap, familial amyloidotic polyneuropathy,gclc, glutamate cysteine ligase catalytic subunit,gclm, glutamate cysteine ligase modifier subunit,gs-dhn, glutathionyl-1,4 dihydroxynonene,gsh, glutathione,gs-hne, hne-conjugates,gst, glutathione-s-transferase,gtpch, guanosine triphosphate cyclohydrolase i,hasmc, human aortic smooth muscle cells,hcsmc, human coronary smooth muscle cells,herp, homocysteine inducible er protein,hmec, human microvascular endothelial cells,ho-1, heme oxygenase-1,hne, 4-hydroxynonenal,hsp-70/72/90, heat shock proteins-70/ -72/ -90,huvec, human umbilical vein endothelial cells,inos, inducible nitric oxide synthase,ire1, inositol requiring enzyme 1 ire1,ivr, central intervening region,jnk, c-jun n-terminal kinase,keap1, kelch-like ech-associated protein 1,masmc, mouse aortic smooth muscle cells,mek1/2, mitogen activated protein kinase kinase 1/2,mmp-1/2, matrix metalloproteinase-1/ -2,mpec, mouse pancreatic islet endothelial cells,nac, n-acetylcysteine,nfκb, nuclear factor kappa b,no, nitric oxide,nqo1, nad(p)h quinone oxidoreductase,nrf2, nuclear factor-e2-related factor 2,oxldl, oxidized low density lipoprotein,pcec, porcine cerebral endothelial cells,pdgf, platelet-derived growth factor,pdi, protein disulfide isomerases,perk, protein kinase-like endoplasmic reticulum kinase,15d-pgj2, 15-deoxy-delta (12,14) prostaglandin-j2,pkc, protein kinase c,pufas, polyunsaturated fatty acids,rasmc, rat aortic smooth muscle cells,ros, reactive oxygen species,rvsmc, rat vascular smooth muscle cells,smc, smooth muscle cell,tbhp, tert-butylhydroperoxide,tkr, tyrosine kinase receptor,upr, unfolded protein response,xct, cystine/glutamate amino acid transporter,4-hydroxynonenal,vascular biology,endothelial cells,vascular smooth muscle cells,redox signaling,nrf2
akt, protein kinase b, ar, aldose reductase, are, antioxidant response element, ap-1, activator protein-1, atf6, activating transcription factor 6, bh4, tetrahydrobiopterin, baec, bovine aortic endothelial cells, blmvec, bovine lung microvascular vein endothelial cells, bpaec, bovine pulmonary arterial endothelial cells, btb, broad complex tramtrack and bric–brac domain, chop, c/ebp-homologous protein, creb, camp response element-binding protein, egfr, epidermal growth factor receptor, elf2α, eukaryotic translation initiation factor 2α, elk1, ets domain-containing protein, enos, endothelial nitric oxide synthase, epre, electrophile response element, er, endoplasmic reticulum, erad, endoplasmic reticulum assisted degradation, erk1/2, extracellular signal-regulated kinase 1/2, fak, focal adhesion kinase, fap, familial amyloidotic polyneuropathy, gclc, glutamate cysteine ligase catalytic subunit, gclm, glutamate cysteine ligase modifier subunit, gs-dhn, glutathionyl-1,4 dihydroxynonene, gsh, glutathione, gs-hne, hne-conjugates, gst, glutathione-s-transferase, gtpch, guanosine triphosphate cyclohydrolase i, hasmc, human aortic smooth muscle cells, hcsmc, human coronary smooth muscle cells, herp, homocysteine inducible er protein, hmec, human microvascular endothelial cells, ho-1, heme oxygenase-1, hne, 4-hydroxynonenal, hsp-70/72/90, heat shock proteins-70/ -72/ -90, huvec, human umbilical vein endothelial cells, inos, inducible nitric oxide synthase, ire1, inositol requiring enzyme 1 ire1, ivr, central intervening region, jnk, c-jun n-terminal kinase, keap1, kelch-like ech-associated protein 1, masmc, mouse aortic smooth muscle cells, mek1/2, mitogen activated protein kinase kinase 1/2, mmp-1/2, matrix metalloproteinase-1/ -2, mpec, mouse pancreatic islet endothelial cells, nac, n-acetylcysteine, nfκb, nuclear factor kappa b, no, nitric oxide, nqo1, nad(p)h quinone oxidoreductase, nrf2, nuclear factor-e2-related factor 2, oxldl, oxidized low density lipoprotein, pcec, porcine cerebral endothelial cells, pdgf, platelet-derived growth factor, pdi, protein disulfide isomerases, perk, protein kinase-like endoplasmic reticulum kinase, 15d-pgj2, 15-deoxy-delta (12,14) prostaglandin-j2, pkc, protein kinase c, pufas, polyunsaturated fatty acids, rasmc, rat aortic smooth muscle cells, ros, reactive oxygen species, rvsmc, rat vascular smooth muscle cells, smc, smooth muscle cell, tbhp, tert-butylhydroperoxide, tkr, tyrosine kinase receptor, upr, unfolded protein response, xct, cystine/glutamate amino acid transporter, 4-hydroxynonenal, vascular biology, endothelial cells, vascular smooth muscle cells, redox signaling, nrf2