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      Effect of Premelting on Conductivity of DNA-Lipid Films

      Author(s): , , , ,
      Publication date Created:
      Publication date (Print):
      Journal: Research Letters in Nanotechnology
      Publisher: Hindawi Limited

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          Abstract

          We have measured temperature-dependent (between 20 and 80 ∘ C) electrical conductivity and molecular structure (Raman spectroscopy) of DNA-lipid cast film. Our findings show that the conductivity is strongly influenced by premelting effects in the molecular structure starting near physiological temperatures ( ∼ 40 ∘ C), prior to the global DNA denaturation.

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          Recent advances on electromigration in very-large-scale-integration of interconnects

          K N Tu (2003)
          Article 0 comments Cited 83 times – based on 0 reviews     Review now
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            Homologous pairing in stretched supercoiled DNA.

            T Strick, D Charmot-Bensimon, V Croquette (1998)
            By using elastic measurements on single DNA molecules, we show that stretching a negatively supercoiled DNA activates homologous pairing in physiological conditions. These experiments indicate that a stretched unwound DNA locally denatures to alleviate the force-driven increase in torsional stress. This is detected by hybridization with 1 kb of homologous single-stranded DNA probes. The stretching force involved (approximately 2 pN) is small compared with those typically developed by molecular motors, suggesting that this process may be relevant to DNA processing in vivo. We used this technique to monitor the progressive denaturation of DNA as it is unwound and found that distinct, stable denaturation bubbles formed, beginning in A+T-rich regions.
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              Dependence of the Raman signature of genomic B-DNA on nucleotide base sequence.

              Hong Deng, Victor Bloomfield, James Benevides … (1999)
              The vibrational spectra of four genomic and two synthetic DNAs, encompassing a wide range in base composition [poly(dA-dT). poly(dA-dT), 0% G + C; Clostridium perfringens DNA, 27% G + C; calf thymus DNA, 42% G + C; Escherichia coli DNA, 50% G + C; Micrococcus luteus DNA, 72% G + C; poly(dG-dC).poly(dG-dC), 100% G + C] (dA: deoxyadenosine; dG: deoxyguanosine; dC: deoxycytidine; dT: thymidine), have been analyzed using Raman difference methods of high sensitivity. The results show that the Raman signature of B DNA depends in detail upon both genomic base composition and sequence. Raman bands assigned to vibrational modes of the deoxyribose-phosphate backbone are among the most sensitive to base sequence, indicating that within the B family of conformations major differences occur in the backbone geometry of AT- and GC-rich domains. Raman bands assigned to in-plane vibrations of the purine and pyrimidine bases-particularly of A and T-exhibit large deviations from the patterns expected for random base distributions, establishing that Raman hypochromic effects in genomic DNA are also highly sequence dependent. The present study provides a basis for future use of Raman spectroscopy to analyze sequence-specific DNA-ligand interactions. The demonstration of sequence dependency in the Raman spectrum of genomic B DNA also implies the capability to distinguish genomic DNAs by means of their characteristic Raman signatures. Copyright 1999 John Wiley & Sons, Inc.
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                Author and article information

                Journal
                Title: Research Letters in Nanotechnology
                Abbreviated Title: Research Letters in Nanotechnology
                Publisher: Hindawi Limited
                ISSN (Print): 1687-6849
                ISSN (Electronic): 1687-6857
                Publication date Created: 2009
                Publication date (Print): 2009
                Volume: 2009
                Issue:
                Pages: 1-5
                Article
                DOI: 10.1155/2009/540257
                SO-VID: 68f014f2-0ac5-4412-9f6f-b0d2e8797414
                Copyright © © 2009
                License:

                http://creativecommons.org/licenses/by/3.0/

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