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      Copper and Zinc Metabolism in Aminonucleoside-Induced Nephrotic Syndrome

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          Abstract

          Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/l00 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had proteinuria (days 3-10), high urinary Cu (days 1,2,4-10) and Zn (days 3-10) excretion. On day 10, nephrotic rats had: (a) albuminuria, hypoalbuminemia, hypoproteinemia, high urine and low serum levels of ceruloplasmin; (b) low Cu and Zn serum levels; (c) high clearance and fractional excretion of Cu and Zn, and (d) low kidney and liver Cu content and essentially normal tissue Zn levels. The alterations in Cu metabolism were more intense than those in Zn metabolism. Urine Cu and Zn showed a positive correlation with urine total protein on days 3-10 which suggests that high urinary excretion of Cu and Zn may be due to the excretion of its carrier proteins. In conclusion, these rats did not show a typical Zn deficiency but a clear decrease in Cu in the liver and kidney.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1994
          1994
          16 December 2008
          : 66
          : 1
          : 87-92
          Affiliations
          aDepartment of Nephrology and Mineral Metabolism, and bDepartment of Physiology of Nutrition, Instituto Nacional de la Nutrición ‘Salvador Zubirán’; cMolecular Biology Laboratory, Biology Department, Facultad de Ciencias, Universidad Nacional Autónoma de México; dDepartment of Nephrology, Instituto Nacional de Cardiología ‘Ignacio Chávez’, Mexico City, México
          Article
          187772 Nephron 1994;66:87–92
          10.1159/000187772
          8107960
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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