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      Corticosteroids stimulate selectively transforming growth factor (TGF)-beta receptor type III expression in transdifferentiating hepatic stellate cells.

      1 , , ,

      Journal of hepatology

      Elsevier BV

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          Abstract

          Transforming growth factor (TGF)-beta receptors mediate TGF-beta signaling in activated hepatic stellate cells (HSC). This leads to pleiotropic cellular effects, e.g. to the production of extracellular matrix which is a hallmark for the development of liver fibrosis. Glucocorticoids and their receptors interact with the TGF-beta signaling pathway on the transcriptional and translational level.

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          Author and article information

          Journal
          J. Hepatol.
          Journal of hepatology
          Elsevier BV
          0168-8278
          0168-8278
          Jan 2004
          : 40
          : 1
          Affiliations
          [1 ] Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. wickert@unicum.de
          Article
          S0168827803005270
          10.1016/j.jhep.2003.09.026
          14672616

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