In vivo Assessment of Ectoin: A Randomized, Vehicle-Controlled Clinical Trial

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Abstract

The aim of the study was to assess an Ectoin formulation with regard to the antiageing properties. The study was designed as a monocentric, randomized, double-blind application test, in order to ensure the compatibility and the efficacy of Ectoin in comparison to a vehicle emulsion. A total of 104 voluntary healthy female test subjects were included in the study. Moisturizing properties as well as other parameters of skin ageing, like skin surface structure and skin elasticity, were determined for treatment A (vehicle) and treatment B (with 2% Ectoin) versus an untreated control. Statistical evaluations according to the Wilcoxon rank-sum test indicate a general preference for the Ectoin treatment by the test subjects in both the application and the efficacy tests. None of the participating test subjects had any side effects throughout the study. In terms of antiageing properties, previous in vitro studies could be confirmed by this clinical trial, clarifying that the natural cell protection concept of Ectoin is transferable to skin care with manifold benefits.

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Most cited references 17

Record: found
Abstract: found
Article: not found

EEMCO guidance for the assessment of stratum corneum hydration: electrical methods

E. Berardesca (1997)

The improvement of stratum corneum hydration is one of the most important claims in the cosmetic industry.

0 comments Cited 84 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.

J Krutmann, T. Ruzicka, H Sies … (1999)

Mutations of mitochondrial (mt) DNA accumulate during normal aging. The most frequent mutation is a 4,977-base pair deletion also called the common deletion, which is increased in photoaged skin. Oxidative stress may play a major role in the generation of large scale mtDNA deletions, but direct proof for this has been elusive. We therefore assessed whether the common deletion can be generated in vitro through UV irradiation and whether reactive oxygen species are involved in this process. Normal human fibroblasts were repetitively exposed to sublethal doses of UVA radiation and assayed for the common deletion employing a semiquantitative polymerase chain reaction technique. There was a time/dose-dependent generation of the common deletion, attributable to the generation of singlet oxygen, since the common deletion was diminished when irradiating in the presence of singlet oxygen quenchers, but increased when enhancing singlet oxygen half-life by deuterium oxide. The induction of the common deletion by UVA irradiation was mimicked by treatment of unirradiated cells with singlet oxygen produced by the thermodecomposition of an endoperoxide. These studies provide evidence for the involvement of reactive oxygen species in the generation of aging-associated mtDNA lesions in human cells and indicate a previously unrecognized role of singlet oxygen in photoaging of human skin.

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1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira

Erwin Galinski, Hans G Trüper, Heinz-Peter PFEIFFER (1985)

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Author and article information

Journal

Journal ID (publisher-id): SPP

Journal ID (nlm-ta): Skin Pharmacol Physiol

Journal ID (doi): 10.1159/issn.1660-5527

Title: Skin Pharmacology and Physiology

Publisher: S. Karger AG

ISSN (Print): 1660-5527

ISSN (Electronic): 1660-5535

Publication date Subscription-year: 2007

Publication date (Print): June 2007

Publication date (Electronic): 23 May 2007

Volume: 20

Issue: 4

Pages: 211-218

Affiliations

Institute of Experimental Dermatology, University of Witten/Herdecke, Witten, Germany

Article

Publisher ID: 103204 Other ID: Skin Pharmacol Appl Skin Physiol 2007;20:211–218

DOI: 10.1159/000103204

PubMed ID: 17519560

SO-VID: 691f11ba-b8b0-4be3-929d-ca667f7a01ff

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 December 2006

Date accepted : 02 April 2007

Page count

Figures: 5, Tables: 4, References: 29, Pages: 8

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