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      • Record: found
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      Sulfonylureas Stimulate Renin Secretion from the Perfused Kidney of the Rat

      a , b

      Nephron

      S. Karger AG

      Tolbutamide, Glibenclamide, Chlorpropamide, Calcium, Renin secretion, Perfused kidney, Rat, cAMP

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          Abstract

          To elucidate whether sulfonylureas directly influence renin secretion, the effect of tolbutamide, glibenclamide, or chlorpropamide on renin secretion was investigated by using the perfused kidney of the rat. The isolated kidneys of male Wistar rats (200–250 g) were perfused with a medium containing 2 µM tolbutamide, 2 µM glibenclamide, and 2 µM chlorpropamide, respectively. Renin activity significantly increased from a basal value of 11.7 ± 3.6 to a peak value of 20.6 ± 5.5 ng/Ang I/ml/h with tolbutamide, from 14.4 ± 4.6 to 32.7 ± 6.5 ng/Ang I/ml/h with glibenclamide, and from 15.0 ± 4.9 to 30.4 ± 6.1 ng/Ang I/ml/h with chlorpropamide. The cAMP concentration in the effluent was not changed by the addition of the sulfonylureas. In kidneys perfused with a calcium-free medium, glibenclamide produced a significant increase in renin activity from a basal value of 13.4 ± 2.1 to a peak value of 30.6 ± 3.4 ng Ang I/ml/h. These results suggest that sulfonylureas stimulate renin secretion from perfused rat kidneys.

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          Most cited references 4

          • Record: found
          • Abstract: found
          • Article: not found

          A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.

          We have isolated a cDNA encoding a novel isoform of the sulfonylurea receptor from a mouse heart cDNA library. Coexpression of this isoform and BIR (Kir6.2) in a mammalian cell line elicited ATP-sensitive K+ (KATP) channel currents. The channel was effectively activated by both diazoxide and pinacidil, which is the feature of smooth muscle KATP channels. Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2). The 42 amino acid residues located in the carboxyl-terminal end of this novel sulfonylurea receptor is, however, divergent from that of SUR2 but highly homologous to that of the pancreatic one (SUR1). Therefore, this short part of the carboxyl terminus may be important for diazoxide activation of KATP channels. The reverse transcription-polymerase chain reaction analysis showed that mRNA of this clone was ubiquitously expressed in diverse tissues, including brain, heart, liver, urinary bladder, and skeletal muscle. These results suggest that this novel isoform of sulfonylurea receptor is a subunit reconstituting the smooth muscle KATP channel.
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            • Record: found
            • Abstract: not found
            • Article: not found

            Cardiovascular and biological effects of K+ channel openers, a class of drugs with vasorelaxant and cardioprotective properties

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              • Record: found
              • Abstract: not found
              • Article: not found

              The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1999
                1999
                13 January 1999
                : 81
                : 1
                : 67-71
                Affiliations
                aYonago Hakuai Hospital, and bTottori University College of Medical Care Technology, Yonago, Japan
                Article
                45248 Nephron 1999;81:67–71
                10.1159/000045248
                9884422
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, References: 26, Pages: 5
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45248
                Categories
                Original Paper

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