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      Cerebroarterial Relaxations Mediated by Nitric Oxide Derived from Endothelium and Vasodilator Nerve

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          Abstract

          Purposes of this study were to determine whether: (1) nitric oxide is involved in endothelium-dependent relaxation in helical strips of dog cerebral arteries; (2) relaxing factor distinct from NO is also involved, and (3) susceptibility to N<sup>G</sup>-nitro- L-arginine ( L-NA), an NO synthase inhibitor, of the response to mediators liberating NO from the endothelium and nerve differs. Changes in isometric tension were recorded. In the strips contracted with prostaglandin F2α, substance P and arginine vasopressin produced a relaxation which was abolished or reversed to a contraction by endothelium denudation. The relaxations were not influenced by indomethacin but were suppressed dose-dependently by L-NA, as was the response to nicotine that stimulates the non-adrenergic, non-cholinergic vasodilator nerve and liberates NO. The inhibitions were reversed by L- but not D-arginine. NO (acidified NaNO<sub>2</sub>)-induced relaxations were not reduced by L-NA. The inhibitory effect was greater in the responses to vasopressin than substance P; however, there was no significant difference in the response to nicotine vs. the peptides. Substance P increased the level of cyclic guanosine monophosphate (GMP) in the artery strips with the intact endothelium, the effect being abolished by endothelium denudation, L-NA and oxyhemoglobin. Relaxations caused by adenosine triphosphate (ATP) and adenosine diphosphate (ADP) were dependent partially on the endothelium. Treatment with L-NA attenuated the ATP-induced relaxation in the strips with endothelium but did not alter the response of denuded strips. It may be concluded that endothelium-dependent relaxations caused by substance P, vasopressin, ATP and ADP in dog cerebral arteries are mediated solely via NO that activates guanylate cyclase and increases the production of cyclic GMP. Susceptibility to L-NA of NO synthase in the endothelium and vasodilator nerve does not appear to differ significantly.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1993
          1993
          23 September 2008
          : 30
          : 2
          : 61-67
          Affiliations
          Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan
          Article
          158976 J Vasc Res 1993;30:61–67
          10.1159/000158976
          7684937
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Research Paper

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