121
views
0
recommends
+1 Recommend
0 collections
    4
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

      Cell

      Animals, CHO Cells, Carrier Proteins, genetics, isolation & purification, pharmacology, Chromatography, High Pressure Liquid, Cricetinae, Fasting, physiology, Feeding Behavior, GTP-Binding Proteins, Humans, Hypothalamus, chemistry, cytology, Intracellular Signaling Peptides and Proteins, Kidney, Male, Molecular Sequence Data, Neurons, drug effects, Neuropeptides, Orexin Receptors, Protein Precursors, RNA, Messenger, metabolism, Rabbits, Rats, Rats, Wistar, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, Sequence Homology, Amino Acid

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.

          Related collections

          Author and article information

          Journal
          9491897

          Comments

          Comment on this article