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The role of the human hippocampus in familiarity-based and recollection-based recognition memory
Author(s):
John T. Wixted
,
Larry R. Squire
Publication date
Created:
December 2010
Publication date
(Print):
December 2010
Journal:
Behavioural Brain Research
Publisher:
Elsevier BV
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Abstract
The ability to recognize a previously encountered stimulus is dependent on the structures of the medial temporal lobe and is thought to be supported by two processes, recollection and familiarity. A focus of research in recent years concerns the extent to which these two processes depend on the hippocampus and on the other structures of the medial temporal lobe. One view holds that the hippocampus is important for both processes, whereas a different view holds that the hippocampus supports only the recollection process and the perirhinal cortex supports the familiarity process. One approach has been to study patients with hippocampal lesions and to contrast old/new recognition (which can be supported by familiarity) to free recall (which is supported by recollection). Despite some early case studies suggesting otherwise, several group studies have now shown that hippocampal patients exhibit comparable impairments on old/new recognition and free recall. These findings suggest that the hippocampus is important for both recollection and familiarity. Neuroimaging studies and Receiver Operating Characteristic analyses also initially suggested that the hippocampus was specialized for recollection, but these studies involved a strength confound (strong memories have been compared to weak memories). When steps are taken to compare strong recollection-based memories with strong familiarity-based memories, or otherwise control for memory strength, evidence for a familiarity signal (as well as a recollection signal) is evident in the hippocampus. These findings suggest that the functional organization of the medial temporal lobe is probably best understood in terms unrelated to the distinction between recollection and familiarity. Copyright © 2010 Elsevier B.V. All rights reserved.
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Embodied Memory
Author and article information
Journal
Title:
Behavioural Brain Research
Abbreviated Title:
Behavioural Brain Research
Publisher:
Elsevier BV
ISSN (Print):
01664328
Publication date Created:
December 2010
Publication date (Print):
December 2010
Volume
: 215
Issue
: 2
Pages
: 197-208
Article
DOI:
10.1016/j.bbr.2010.04.020
PMC ID:
2939282
PubMed ID:
20412819
SO-VID:
698bfa33-d4a6-41f1-bea6-6aaea776d968
Copyright ©
© 2010
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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