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      Hemodynamic Theory of Progressive Renal Disease: A 10-Year Update in Brief Review

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      American Journal of Kidney Diseases

      Elsevier BV

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          Abstract

          Experimental studies have suggested that glomerular hypertension is ultimately damaging to the kidney. Prevention of glomerular hypertension by dietary protein restriction or antihypertensive therapy lessens glomerular injury in several experimental models of chronic renal disease. Glomerular hypertension and hyperfiltration also occur in humans with diabetes mellitus, solitary or remnant kidneys, and various forms of acquired renal disease. Clinical studies are beginning to show that dietary protein restriction and antihypertensive therapy may slow progression in these disorders. Large multicenter trials are currently under way to better define the effects of these therapeutic maneuvers on the progression of chronic renal disease.

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          Author and article information

          Journal
          American Journal of Kidney Diseases
          American Journal of Kidney Diseases
          Elsevier BV
          02726386
          July 1993
          July 1993
          : 22
          : 1
          : 98-104
          Article
          8322801
          © 1993

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