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      Performance Evaluation of Calypso 4D Localization and Kilovoltage Image Guidance Systems for Interfraction Motion Management of Prostate Patients

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          Abstract

          Prostate cancer represents a model site for advances in understanding inter- and intrafraction motion for radiotherapy. In this study, we examined the correlation of the electromagnetic transponder system/Calypso 4D Localization System with conventional on-board imaging (OBI) using kilovoltage imaging. Initially using a quality assurance (QA) phantom and subsequently using data of seven patients, the vector distances between Calypso- and OBI-recorded shifts were compared using the t-test. For the 30 phantom measurements, the average differences between the measured Calypso offset and the calculated OBI shift were 0.4 ± 0.4, 0.2 ± 0.3, and 0.4 ± 0.3 mm in the lateral, longitudinal, and vertical directions, respectively ( p = 0.73, p = 0.91, and p = 0.99, respectively), and the average difference vector for all sessions was 0.8 ± 0.4 mm. For the 259 patient measurements, the average differences between the measured Calypso offset and the calculated OBI shift were 0.7 ± 0.5, 1.1 ± 0.9, and 1.2 ± 0.9 mm in the lateral, longitudinal, and vertical directions, respectively ( p = 0.45, p = 0.28, and p = 0.56, respectively), and the average difference vector for all sessions was 2.1 ± 1.0 mm. Our results demonstrated good correlation between Calypso and OBI. While other studies have explored the issue of Calypso/OBI correlation, our analysis is unique in our use of phantom validation and in our performing the patient analysis on an initial population prior to routine setup using Calypso without OBI. Implications for Calypso's role as a QA tool are discussed.

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          Author and article information

          Journal
          ScientificWorldJournal
          ScientificWorldJournal
          TSWJ
          The Scientific World Journal
          TheScientificWorldJOURNAL
          2356-6140
          1537-744X
          2009
          12 June 2009
          : 9
          : 449-458
          Affiliations
          Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
          Author notes

          Academic Editor: Anthony Atala

          Article
          870212
          10.1100/tsw.2009.61
          5823203
          19526184
          69e29745-b27b-4c57-a4ae-41a37d818377
          Copyright © 2009 Tomi Ogunleye et al.

          This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          Categories
          Research Article

          Uncategorized

          calypso, prostate, obi, tracking, motion, electromagnetic localization, real-time

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