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      Cerebrospinal fluid vasopressin and symptom severity in children with autism : CSF vasopressin concentration and autism

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          Abstract

          <p class="first" id="P3">Autism is a brain disorder characterized by social impairments. Progress in understanding autism has been hindered by difficulty in obtaining brain-relevant tissues (eg, cerebrospinal fluid [CSF]) by which to identify markers of disease and targets for treatment. Here, we overcome this barrier by providing evidence that mean CSF concentration of the “social” neuropeptide arginine vasopressin (AVP) is lower in children with autism versus controls. CSF AVP concentration also significantly differentiates individual cases from controls and is associated with greater social symptom severity in children with autism. These findings indicate that AVP may be a promising CSF marker of autism’s social deficits. </p>

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          Author and article information

          Journal
          Annals of Neurology
          Ann Neurol
          Wiley
          03645134
          August 28 2018
          Affiliations
          [1 ]Department of Psychiatry and Behavioral Sciences; Stanford University; Stanford CA 94305
          [2 ]Department of Comparative Medicine; Stanford University; Stanford CA 94305
          [3 ]Department of Neurology and Neurological Sciences; Stanford University; Stanford CA 94305
          [4 ]Departments of Neurology, Pediatrics, Institute of Human Genetics, Weill Institute for Neurosciences; University of California San Francisco; San Francisco CA 94158
          [5 ]Section on Behavioral Pediatrics, Intramural Research Program, National Institute of Mental Health; Bethesda MD 20814
          Article
          10.1002/ana.25314
          6719782
          30152888
          69f527f4-1752-4681-bace-f51bc639094d
          © 2018

          http://doi.wiley.com/10.1002/tdm_license_1.1

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