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Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
Devin Razavi-Shearer ,
Ivane Gamkrelidze ,
Mindie H Nguyen ,
Ding-Shinn Chen ,
Pierre Van Damme ,
Zaigham Abbas ,
Maheeba Abdulla ,
Antoine Abou Rached ,
Danjuma Adda ,
Inka Aho ,
Ulus Akarca ,
Fuad Hasan ,
Faryal Al Lawati ,
Khalid Al Naamani ,
Hamad Ibrahim Al-Ashgar ,
Seyed M Alavian ,
Sameer Alawadhi ,
Agustin Albillos ,
Said A Al-Busafi ,
Soo Aleman ,
Faleh Z Alfaleh ,
Abdulrahman A Aljumah ,
Anil C Anand ,
Nguyen Thu Anh ,
Joop E Arends ,
Perttu Arkkila ,
Kostas Athanasakis ,
Abate Bane ,
Ziv Ben-Ari ,
Thomas Berg ,
Abdul R Bizri ,
Sarah Blach ,
Carlos E Brandão Mello ,
Samantha M Brandon ,
Bisi Bright ,
Philip Bruggmann ,
Maurizia Brunetto ,
Maria Buti ,
Henry L Y Chan ,
Asad Chaudhry ,
Rong-Nan Chien ,
Moon S Choi ,
Peer B Christensen ,
Wan-Long Chuang ,
Vladimir Chulanov ,
Mette R Clausen ,
Massimo Colombo ,
Markus Cornberg ,
Benjamin Cowie ,
Antonio Craxi ,
Esther A Croes ,
Diego Alberto Cuellar ,
Chris Cunningham ,
Hailemichael Desalegn ,
Sylvia Drazilova ,
Ann-Sofi Duberg ,
Steve S Egeonu ,
Manal H El-Sayed ,
Chris Estes ,
Karolin Falconer ,
Maria L G Ferraz ,
Paulo R Ferreira ,
Robert Flisiak ,
Sona Frankova ,
Giovanni B Gaeta ,
Javier García-Samaniego ,
Jordan Genov ,
Jan Gerstoft ,
Adrian Goldis ,
Ilias Gountas ,
Richard Gray ,
Mário Guimarães Pessôa ,
Behzad Hajarizadeh ,
Angelos Hatzakis ,
Christophe Hézode ,
Sayed M Himatt ,
Andy Hoepelman ,
Irena Hrstic ,
Yee-Tak T Hui ,
Petr Husa ,
Rohani Jahis ,
Naveed Z Janjua ,
Peter Jarčuška ,
Jerzy Jaroszewicz ,
Sabahattin Kaymakoglu ,
David Kershenobich ,
Loreta A Kondili ,
Aliya Konysbekova ,
Mel Krajden ,
Pavol Kristian ,
Wim Laleman ,
Wai-cheung C Lao ,
Jen Layden ,
Jeffrey V Lazarus ,
Mei-Hsuan Lee ,
Valentina Liakina ,
Young-Suk S Lim ,
Ching-kong K Loo ,
Boris Lukšić ,
Reza Malekzadeh ,
Abraham O Malu ,
Adkhamjon Mamatkulov ,
Michael Manns ,
Rui T Marinho ,
Mojca Maticic ,
Stefan Mauss ,
Muhammad S Memon ,
Maria C Mendes Correa ,
Nahum Mendez-Sanchez ,
Shahin Merat ,
Ammal M Metwally ,
Rosmawati Mohamed ,
Jacques E Mokhbat ,
Christophe Moreno ,
Joel Mossong ,
Fadi H Mourad ,
Beat Müllhaupt ,
Kimberly Murphy ,
Erkin Musabaev ,
Arif Nawaz ,
Helen M Nde ,
Francesco Negro ,
Alexander Nersesov ,
Van Thi Thuy Nguyen ,
Richard Njouom ,
Renovat Ntagirabiri ,
Zuridin Nurmatov ,
Solomon Obekpa ,
Ponsiano Ocama ,
Stephen Oguche ,
Ogu Omede ,
Casimir Omuemu ,
Ohene Opare-Sem ,
Christopher K Opio ,
Necati Örmeci ,
George Papatheodoridis ,
Ken Pasini ,
Nikolay Pimenov ,
Hossein Poustchi ,
Trân D Quang ,
Huma Qureshi ,
Alnoor Ramji ,
Kathryn Razavi-Shearer ,
Berhane Redae ,
Henk W Reesink ,
Cielo Yaneth Rios ,
Gabriela Rjaskova ,
Sarah Robbins ,
Lewis R Roberts ,
Stuart K Roberts ,
Stephen D Ryder ,
Rifaat Safadi ,
Olga Sagalova ,
Riina Salupere ,
Faisal M Sanai ,
Juan F Sanchez-Avila ,
Vivek Saraswat ,
Christoph Sarrazin ,
Jonathan D Schmelzer ,
Ivan Schréter ,
Julia Scott ,
Carole Seguin-Devaux ,
Samir R Shah ,
Ala I Sharara ,
Manik Sharma ,
Gamal E Shiha ,
Tesia Shin ,
William Sievert ,
Jan Sperl ,
Peter Stärkel ,
Catherine Stedman ,
Vana Sypsa ,
Frank Tacke ,
Soek S Tan ,
Junko Tanaka ,
Krzysztof Tomasiewicz ,
Petr Urbanek ,
Adriaan J van der Meer ,
Hans Van Vlierberghe ,
Stefano Vella ,
Adriana Vince ,
Yasir Waheed ,
Imam Waked ,
Nicholas Walsh ,
Nina Weis ,
Vincent W Wong ,
Joseph Woodring ,
Cesar Yaghi ,
Hwai-I Yang ,
Chung-Lin Yang ,
Kakharman Yesmembetov ,
Ayman Yosry ,
Man-Fung Yuen ,
Muhammed Aasim M Yusuf ,
Stefan Zeuzem ,
Homie Razavi
June 2018
June 2018
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Abstract
The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate
viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus
(HBV) infection, existing therapies to control viral replication and prophylaxis to
minimise mother-to-child transmission make elimination of HBV feasible. We aimed to
estimate the national, regional, and global prevalence of HBsAg in the general population
and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis,
and treatment.