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      Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

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          ABSTRACT

          Inflammatory bowel disease (IBD) is a group of chronic relapsing disorders whose etiology has not been fully explained. Therefore, available therapeutic approaches for IBD patients are still insufficient. Current treatment strategies are targeted to immune system dysfunctions, often associated with alternations in the microbiota, which contribute to the development of chronic intestinal inflammation. Therapeutics include anti-inflammatory drugs such as aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics, and biological agents such as infliximab and vedolizumab. Auxiliary therapies involve a balanced and personalized diet, healthy lifestyle, avoiding stress, as well as dietary supplements. In this review, we discuss the use of bovine colostrum (BC) as a therapeutic agent, including its advantages and contraindications. We summarize our knowledge on well-researched BC constituents and their effects on the gastrointestinal tract as evidenced in in vitro and in vivo studies.

          Abstract

          In this review, we discuss possibilities of bovine colostrum (BC) application in patients with inflammatory bowel disease. The article summarizes its advantages and contraindications and focuses on the effects of BC on the gastrointestinal tract.

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          Most cited references167

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          Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

          Lance W. Peterson, David Artis (2014)
          The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.
          Article 0 comments Cited 670 times – based on 0 reviews     Review now
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            Inflammatory bowel disease: pathogenesis.

            Yi-Zhen Zhang, Yong-Yu Li (2014)
            Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been a worldwide health-care problem with a continually increasing incidence. It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut, catalyzed by the genetic susceptibility of the individual. Although the etiology of IBD remains largely unknown, it involves a complex interaction between the genetic, environmental or microbial factors and the immune responses. Of the four components of IBD pathogenesis, most rapid progress has been made in the genetic study of gut inflammation. The latest internationally collaborative studies have ascertained 163 susceptibility gene loci for IBD. The genes implicated in childhood-onset and adult-onset IBD overlap, suggesting similar genetic predispositions. However, the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD. Meanwhile, the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD, as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation. Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms, including the innate and adaptive immunity, and the interactions between genetic factors and microbial and environmental cues. In this review, we provide an update on the major advances that have occurred in above areas.
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              Interleukin-10-deficient mice develop chronic enterocolitis.

              Ralf Kühn, Jürgen Löhler, Donna Rennick … (1993)
              Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL-10-deficient mice, generated by gene targeting, lymphocyte development and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis. Alterations in intestine include extensive mucosal hyperplasia, inflammatory reactions, and aberrant expression of major histocompatibility complex class II molecules on epithelia. In contrast, mutants kept under specific pathogen-free conditions develop only a local inflammation limited to the proximal colon. These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
              Article 0 comments Cited 301 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Michał Sienkiewicz
                Patrycja Szymańska
                Jakub Fichna:
                ORCID: https://orcid.org/0000-0002-8443-4417
                Journal
                Journal ID (nlm-ta): Adv Nutr
                Journal ID (iso-abbrev): Adv Nutr
                Journal ID (publisher-id): advances
                Title: Advances in Nutrition
                Publisher: Oxford University Press
                ISSN (Print): 2161-8313
                ISSN (Electronic): 2156-5376
                Publication date Collection: March 2021
                Publication date (Electronic): 17 October 2020
                Publication date PMC-release: 17 October 2020
                Volume: 12
                Issue: 2
                Pages: 533-545
                Affiliations
                Department of Biochemistry, Faculty of Medicine, Medical University of Lodz , Lodz, Poland
                Department of Hemostasis and Hemostatic Disorders, Faculty of Health Sciences, Medical University of Lodz , Lodz, Poland
                Department of Biochemistry, Faculty of Medicine, Medical University of Lodz , Lodz, Poland
                Author notes
                Address correspondence to JF (e-mail: jakub.fichna@ 123456umed.lodz.pl )
                Author information
                https://orcid.org/0000-0002-8443-4417
                Article
                Publisher ID: nmaa120
                DOI: 10.1093/advances/nmaa120
                PMC ID: 8009748
                PubMed ID: 33070186
                SO-VID: 69fc39ad-5176-4485-a309-65fab44eabed
                Copyright © © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@ 123456oup.com

                History
                Date received : 13 May 2020
                Date revision received : 06 July 2020
                Date accepted : 03 September 2020
                Page count
                Pages: 13
                Funding
                Funded by: Medical University of Lodz;
                Award ID: 503/1-156-04/503-11-001-19-00
                Categories
                Subject: Review
                Subject: AcademicSubjects/MED00060

                Keywords: bovine colostrum,inflammatory bowel disease,ibd,treatment,gastrointestinal,cytokines,immunoglobulins
                Data availability:
                Keywords: bovine colostrum, inflammatory bowel disease, ibd, treatment, gastrointestinal, cytokines, immunoglobulins

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