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      Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM)

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          Abstract

          Background

          With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour.

          Methods

          The constituents of JWXY capsule were identified by ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry analyses. We analysed behaviours of depression-like zebrafish in the novel tank with an automatic 3D video-tracking system and conducted the colour preference test, as well detected physiological changes after sertraline and JWXY capsule treatments.

          Results

          Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine. JWXY capsule especially improved the inhibited exploratory behaviour caused by reserpine. In addition, with the onset of depressive behaviour, zebrafish exhibited alterations in cognitive behaviour as indicated by colour preference changes. However, compared with sertraline, JWXY capsule was more efficaciously in rescuing this change in the colour preference pattern. Moreover, an increased level of cortisol, increased expression of tyrosine hydroxylase (TH) and decreased monoamine neurotransmitters, including serotonin (5-HT) and noradrenaline, were involved in the depressive behaviours. In addition, sertraline and JWXY capsule rescued the depressive phenotype and cognitive behaviour of zebrafish by altering the levels of endogenous cortisol and monoamine neurotransmitters.

          Conclusions

          JWXY capsule was more effectively than sertraline in rescuing reserpine-induced depression and cognitive disorder in zebrafish. Potentially, our study can provide new insights into the clinical treatment of depression and the mechanism of action of JWXY capsule.

          Electronic supplementary material

          The online version of this article (10.1186/s12993-018-0145-8) contains supplementary material, which is available to authorized users.

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          Most cited references43

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          Zebrafish as an emerging model for studying complex brain disorders.

          Allan V. Kalueff, Adam Stewart, Robert Gerlai (2014)
          The zebrafish (Danio rerio) is rapidly becoming a popular model organism in pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently used to increase our understanding of brain function, dysfunction, and their genetic and pharmacological modulation. Here we review the developing utility of zebrafish in the analysis of complex brain disorders (including, e.g., depression, autism, psychoses, drug abuse, and cognitive deficits), also covering zebrafish applications towards the goal of modeling major human neuropsychiatric and drug-induced syndromes. We argue that zebrafish models of complex brain disorders and drug-induced conditions are a rapidly emerging critical field in translational neuroscience and pharmacology research. Copyright © 2013 Elsevier Ltd. All rights reserved.
          Article 0 comments Cited 278 times – based on 0 reviews     Review now
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            The serotonergic system in fish.

            C Lillesaar (2011)
            Neurons using serotonin (5-HT) as neurotransmitter and/or modulator have been identified in the central nervous system in representatives from all vertebrate clades, including jawless, cartilaginous and ray-finned fishes. The aim of this review is to summarize our current knowledge about the anatomical organization of the central serotonergic system in fishes. Furthermore, selected key functions of 5-HT will be described. The main focus will be the adult brain of teleosts, in particular zebrafish, which is increasingly used as a model organism. It is used to answer not only genetic and developmental biology questions, but also issues concerning physiology, behavior and the underlying neuronal networks. The many evolutionary conserved features of zebrafish combined with the ever increasing number of genetic tools and its practical advantages promise great possibilities to increase our understanding of the serotonergic system. Further, comparative studies including several vertebrate species will provide us with interesting insights into the evolution of this important neurotransmitter system. Copyright © 2011 Elsevier B.V. All rights reserved.
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              Molecular psychiatry of zebrafish

              Adam Stewart, Jeremy Ullmann, William Norton … (2014)
              Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling CNS disorders. In particular, we outline recent genetic and technological developments allowing for in-vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern biological psychiatry research.
              Article 0 comments Cited 65 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Xin Zhao: zhaoxin@nankai.edu.cn
                Dongyan Chen: chendy@nankai.edu.cn
                Xizeng Feng: xzfeng@nankai.edu.cn
                Journal
                Journal ID (nlm-ta): Behav Brain Funct
                Journal ID (iso-abbrev): Behav Brain Funct
                Title: Behavioral and Brain Functions : BBF
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1744-9081
                Publication date (Electronic): 14 June 2018
                Publication date PMC-release: 14 June 2018
                Publication date Collection: 2018
                Volume: 14
                Electronic Location Identifier: 13
                Affiliations
                [1 ]ISNI 0000 0000 9878 7032, GRID grid.216938.7, State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, , Nankai University, ; Tianjin, 300071 China
                [2 ]ISNI 0000 0000 9878 7032, GRID grid.216938.7, Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Department of Histology and Embryology, School of Medicine, , Nankai University, ; Tianjin, 300071 China
                [3 ]ISNI 0000 0000 9878 7032, GRID grid.216938.7, The Institute of Robotics and Automatic Information Systems, , Nankai University, ; Tianjin, 300071 China
                Article
                Publisher ID: 145
                DOI: 10.1186/s12993-018-0145-8
                PMC ID: 6001006
                PubMed ID: 29898741
                SO-VID: 6a0c3035-867d-419d-a9b8-a62025458e23
                Copyright © © The Author(s) 2018
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 1 January 2018
                Date accepted : 1 June 2018
                Funding
                Funded by: the Special Fund for Basic Research on Scientific Instruments from the Chinese National Natural Science Foundation of China
                Award ID: 61327802
                Award Recipient :
                Funded by: National Basic Research Program of China
                Award ID: 2015CB856500
                Award Recipient :
                Funded by: the Chinese National Natural Science Foundation of China
                Award ID: 61633012
                Award ID: U1613220
                Award Recipient :
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © The Author(s) 2018

                ScienceOpen disciplines: Neurology
                Keywords: depression behaviour,tcm,colour preference,monoamines,zebrafish
                Data availability:
                ScienceOpen disciplines: Neurology
                Keywords: depression behaviour, tcm, colour preference, monoamines, zebrafish

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