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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma.
D S Robinson
1 ,
Q Hamid ,
S Ying ,
A Tsicopoulos ,
J Barkans ,
A M Bentley ,
C Corrigan ,
S R Durham ,
A B Kay
Jan 30 1992
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Abstract
In atopic asthma, activated T helper lymphocytes are present in bronchial-biopsy specimens and bronchoalveolar-lavage (BAL) fluid, and their production of cytokines may be important in the pathogenesis of this disorder. Different patterns of cytokine release are characteristic of certain subgroups of T helper cells, termed TH1 and TH2, the former mediating delayed-type hypersensitivity and the latter mediating IgE synthesis and eosinophilia. The pattern of cytokine production in atopic asthma is unknown.