Hemodynamic Response to Exercise after Beta-Adrenergic Blockade in Normal and Labile Hypertensive Patients

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Abstract

In 5 normal persons and in 5 labile hypertensive patients, the hemodynamic response to exercise and its modification after beta-adrenergic blockade, was studied. In labile hypertensive patients, the changes in diastolic and mean blood pressure, left ventricular work and left ventricular stroke work were more pronounced than in normal subjects. After beta-adrenergic blockade, there was no longer a significant difference between the two groups. Moreover, the response of labile hypertensive patients after blockade was quite similar to the response of control group in normal conditions. The pharmacologic agent used Trasicor® did not limit the increase in cardiac output during exercise in the normal group. Its effect seems to be due mainly to a negative chronotropic action.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1970

Publication date (Print): 1970

Publication date (Electronic): 29 October 2008

Volume: 55

Issue: 2

Pages: 105-113

Affiliations

Department of Cardiology, Hospital de Clínicas and Department of Pharmaco-dynamics and Therapeutics, Faculty of Medicine, Universidad de la República, Montevideo

Article

Publisher ID: 169273 Other ID: Cardiology 1970;55:105–113

DOI: 10.1159/000169273

PubMed ID: 4397324

SO-VID: 6a57a5c5-45b3-4e71-8c93-f8d325355af7

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Hemodynamic Response to Exercise after Beta-Adrenergic Blockade in Normal and Labile Hypertensive Patients

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Karger: Cardiovascular System

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