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      Hemodynamic Response to Exercise after Beta-Adrenergic Blockade in Normal and Labile Hypertensive Patients

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          Abstract

          In 5 normal persons and in 5 labile hypertensive patients, the hemodynamic response to exercise and its modification after beta-adrenergic blockade, was studied. In labile hypertensive patients, the changes in diastolic and mean blood pressure, left ventricular work and left ventricular stroke work were more pronounced than in normal subjects. After beta-adrenergic blockade, there was no longer a significant difference between the two groups. Moreover, the response of labile hypertensive patients after blockade was quite similar to the response of control group in normal conditions. The pharmacologic agent used Trasicor® did not limit the increase in cardiac output during exercise in the normal group. Its effect seems to be due mainly to a negative chronotropic action.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1970
          1970
          29 October 2008
          : 55
          : 2
          : 105-113
          Affiliations
          Department of Cardiology, Hospital de Clínicas and Department of Pharmaco-dynamics and Therapeutics, Faculty of Medicine, Universidad de la República, Montevideo
          Article
          169273 Cardiology 1970;55:105–113
          10.1159/000169273
          4397324
          © 1970 S. Karger AG, Basel

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          Page count
          Pages: 9
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