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      Glucoreceptors Located in Different Areas Mediate the Hypoglycemia-Induced Release of Growth Hormone, Prolactin, and Adrenocorticotropin in Man

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          In young male volunteers, the changes in growth hormone (GH), prolactin (PRL), and adrenocorticotropic hormone (ACTH) release in response to insulin injection combined with the infusion of saline, glucose, and fructose were evaluated. Glucose infusion in a dose which prevented insulin hypoglycemia completely abolished endocrine responses. Infusion of fructose, which is known not to cross the blood-brain barrier (BBB), did not influence the GH release during hypoglycemia; however, it inhibited PRL secretion. The ACTH response was slightly attenuated and delayed, while the hypoglycemia-induced rise in cortisol levels was not modified by fructose infusion. These data indicate that the glucoreceptors mediating the signals for a complete counterregulatory neuroendocrine response are not located in a single brain structure. Stimuli for GH release are produced in areas of the central nervous system protected by the BBB, while those for PRL release are presumably present in structures not protected by the BBB. Glucoreceptors triggering ACTH release are located both inside and outside the BBB.

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          Author and article information

          S. Karger AG
          03 April 2008
          : 51
          : 3
          : 365-368
          Institute of Experimental Endocrinology, Center of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia
          125362 Neuroendocrinology 1990;51:365–368
          © 1990 S. Karger AG, Basel

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