12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.

      The Journal of Immunology Author Choice
      Animals, Cell Movement, genetics, immunology, Cells, Cultured, Coculture Techniques, Forkhead Transcription Factors, biosynthesis, Growth Inhibitors, metabolism, physiology, Humans, Immunophenotyping, Interleukin-6, antagonists & inhibitors, Intestinal Mucosa, cytology, Lymphoid Tissue, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Receptors, Lymphocyte Homing, Receptors, Retinoic Acid, T-Lymphocytes, Helper-Inducer, classification, T-Lymphocytes, Regulatory, Transforming Growth Factor beta1, Tretinoin, Vitamin A

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In this study, we report a novel biological function of vitamin A metabolites in conversion of naive FoxP3- CD4+ T cells into a unique FoxP3+ regulatory T cell subset (termed "retinoid-induced FoxP3+ T cells") in both human and mouse T cells. We found that the major vitamin A metabolite all-trans-retinoic acid induces histone acetylation at the FoxP3 gene promoter and expression of the FoxP3 protein in CD4+ T cells. The induction of retinoid-induced FoxP3+ T cells is mediated by the nuclear retinoic acid receptor alpha and involves T cell activation driven by mucosal dendritic cells and costimulation through CD28. Retinoic acid can promote TGF-beta1-dependent generation of FoxP3+ regulatory T cells but decrease the TGF-beta1- and IL-6-dependent generation of inflammatory Th17 cells in mouse T cells. Retinoid-induced FoxP3+ T cells can efficiently suppress target cells and, thus, have a regulatory function typical for FoxP3+ T cells. A unique cellular feature of these regulatory T cells is their high expression of gut-homing receptors that are important for migration to the mucosal tissues particularly the small intestine. Taken together, these results identify retinoids as positive regulatory factors for generation of gut-homing FoxP3+ T cells.

          Related collections

          Author and article information

          Comments

          Comment on this article