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      Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior

      , , , , , ,
      Behavioural Brain Research
      Elsevier BV

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          Abstract

          In the open-field behavior of rodents, Software for Exploring Exploration (SEE) can be used for an explicit design of behavioral endpoints with high genotype discrimination and replicability across laboratories. This ability is demonstrated here in the development of a measure for darting behavior. The behavior of two common mouse inbred strains, C57BL/6J (B6) and DBA/2J (D2), was analyzed across three different laboratories, and under the effect of cocaine or amphetamine. "Darting" was defined as having higher acceleration during progression segments while moving less during stops. D2 mice darted significantly more than B6 mice in each laboratory, despite being significantly less active. These differences were maintained following cocaine administration (up to 20mg/kg) and only slightly altered by amphetamine (up to 5mg/kg) despite a several fold increase in activity. The replicability of darting behavior was confirmed in additional experiments distinct from those used for its design. The strategy leading to the darting measure may be used to develop additional discriminative and replicable endpoints of open-field behavior.

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          Author and article information

          Journal
          Behavioural Brain Research
          Behavioural Brain Research
          Elsevier BV
          01664328
          June 2003
          June 2003
          : 142
          : 1-2
          : 193-205
          Article
          10.1016/S0166-4328(03)00003-2
          12798281
          6a75afee-fa2d-471b-89d7-ac22d8f5d445
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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