Loss of succinate dehydrogenase subunit B (SDHB) as a prognostic factor in advanced ileal well-differentiated neuroendocrine tumors.

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Abstract

Abnormal expression of succinate dehydrogenase, (SDH), in particular of the B subunit (SDHB), is implicated in the pathogenesis of neuroendocrine tumors. This study evaluates the distribution of SDHB in WHO grading G1 and G2 intestinal, well-differentiated neuroendocrine tumors and corresponding lymph node or liver metastases.

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Journal

Journal ID (iso-abbrev): Endocrine

Title: Endocrine

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1559-0100

ISSN (Print): 1355-008X

Publication date (Electronic): Sep 2017

Volume: 57

Issue: 3

Affiliations

[1 ] 1st Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS, Milan, Italy. Massimo.milione@istitutotumori.mi.it.

[2 ] Division of Epidemiology and Biostatistics, European Institute of oncology (IEO), Milan, Italy.

[3 ] 1st Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS, Milan, Italy.

[4 ] Departement of Medical Oncology, IRCCS Foundation National Cancer Institute, Milan, Italy.

[5 ] Istituto Nazionale per lo studio e la cura dei tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy.

[6 ] University of Genoa, Genoa, Italy.

[7 ] Department of Surgery, G.I. Surgery and Liver Transplantation, Istituto Nazionale Tumori (National Cancer Institute), Milan, Italy.

Article

Publisher Item ID: 10.1007/s12020-016-1180-6

DOI: 10.1007/s12020-016-1180-6

PubMed ID: 27905048

SO-VID: 6a98403a-00d4-458e-a3f6-cde8bac76c27

History

Keywords: Ileal NET,Immunochemistry,Prognosis,SDHB

Data availability:

Keywords: Ileal NET, Immunochemistry, Prognosis, SDHB

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