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      Effect of Polyamines on Mesangial Cell Ecto-5′-Nucleotidase and Ecto-ATPase Activity

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          Abstract

          Polyamines were found to modulate the activity of several membrane-bound enzymes, participating in cell growth and differentiation. We have studied the effect of polyamines (spermidine, spermine and putrescine) on rat mesangial cell ectoenzymes: 5′-nucleotidase, Mg<sup>2+</sup>-ATPase and Ca<sup>2+</sup>-ATPase. Ecto-5′-nucleotidase activity was significantly increased after 48 h treatment with spermine and spermidine. Mg<sup>2+</sup>-ATPase was increased only after treatment with spermidine; however, Ca<sup>2+</sup>-ATPase was significantly increased after both spermine and spermidine treatment of mesangial cells. Culture of mesangial cells with putrescine did not change the activity of these ectoenzymes. Increased expression of mesangial cell ecto-ATPase and ecto-5′-nucleotidase after spermine and spermidine treatment could result in an increased production of adenosine, a powerful autacoid interesting with respect to a role of mesangial cells in inflammatory processes.

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          Formation of a Complex Containing ATP, Mg2+, and Spermine

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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            2002
            September 2002
            14 August 2002
            : 92
            : 1
            : 216-218
            Affiliations
            Institute of Nephrology and Hemodialysis, Faculty of Medicine, Niš, Yugoslavia
            Article
            64466 Nephron 2002;92:216–218
            10.1159/000064466
            12187106
            © 2002 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 1, References: 8, Pages: 3
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/64466
            Categories
            Short Communication

            Cardiovascular Medicine, Nephrology

            Ecto-5′-nucleotidase, Ecto-ATPase, Polyamines, Mesangial cells

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