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      Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.

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          Abstract

          Negative symptoms of schizophrenia are insufficiently treated by current antipsychotics. However, research is limited by the lack of validated models. Clinical data indicate that phencyclidine (PCP) abuse may induce symptoms resembling negative symptoms in humans. Based on that, Noda et al. proposed a model of PCP-induced increase of immobility in the forced swim test in mice as a model of depression-like negative symptoms of schizophrenia.

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          Author and article information

          Journal
          Psychopharmacology (Berl.)
          Psychopharmacology
          Springer Nature
          1432-2072
          0033-3158
          May 2012
          : 221
          : 2
          Affiliations
          [1 ] biocrea GmbH, Radebeul, Germany. barbara.langen@biocrea.com
          Article
          10.1007/s00213-011-2567-y
          22147257

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