Natural speech markers of Alzheimer&apos;s disease co-pathology in Lewy body dementias.

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Abstract

An estimated 50% of patients with Lewy body dementias (LBD), including Parkinson's disease dementia (PDD) and Dementia with Lewy bodies (DLB), have co-occurring Alzheimer's disease (AD) that is associated with worse prognosis. This study tests an automated analysis of natural speech as an inexpensive, non-invasive screening tool for AD co-pathology in biologically-confirmed cohorts of LBD patients with AD co-pathology (SYN + AD) and without (SYN-AD).

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Journal

Journal ID (iso-abbrev): Parkinsonism Relat Disord

Title: Parkinsonism & related disorders

Publisher: Elsevier BV

ISSN (Electronic): 1873-5126

ISSN (Print): 1353-8020

Publication date (Electronic): Sep 2022

Volume: 102

Affiliations

[1 ] Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: sanjana.shellikeri@pennmedicine.upenn.edu.

[2 ] Linguistic Data Consortium, University of Pennsylvania, Philadelphia, PA, USA.

[3 ] Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.

[4 ] Linguistic Data Consortium, University of Pennsylvania, Philadelphia, PA, USA; Department of Linguistics, University of Pennsylvania, Philadelphia, PA, USA.

[5 ] Department of Psychology, The Ohio State University, Columbus, OH, USA.

[6 ] Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

[7 ] Parkinson's Disease and Movement Disorders Center, and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.

[8 ] Center for Neurodegenerative Disease Research, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

[9 ] Penn Frontotemporal Degeneration Center and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: naomine@pennmedicine.upenn.edu.

Article

Mid ID: NIHMS1850928 Publisher Item ID: S1353-8020(22)00248-6

DOI: 10.1016/j.parkreldis.2022.07.023

PMC ID: 9680016

PubMed ID: 35985146

SO-VID: 6adc8345-ab9b-4ddd-ab8a-7efec073676b

History

Keywords: Parkinson disease dementia,Speech analysis,Alzheimer's disease,Automatic speech processing,Digital biomarker,Lewy body dementia,Natural language processing

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Keywords: Parkinson disease dementia, Speech analysis, Alzheimer's disease, Automatic speech processing, Digital biomarker, Lewy body dementia, Natural language processing

Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.

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Radiology and Natural Language Processing

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