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      Estradiol Enhances the Action of Neuropeptide Y on in vivo Luteinizing Hormone-Releasing Hormone Release in the Ovariectomized Rhesus Monkey

      ,

      Neuroendocrinology

      S. Karger AG

      hormone release Primates, Estradiol, Neuropeptide Y, Luteinizing hormone-releasing

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          Abstract

          The effect of estrogen on the responsiveness of the luteinizing hormone-releasing hormone (LHRH) neurosecretory system to neuropeptide Y (NPY) stimulation was examined using a push-pull perfusion method in conscious monkeys. NPY, at doses of 10<sup>–6</sup> to 10<sup>–12</sup> M, was infused into the stalk-median eminence (S-ME) of ovariectomized monkeys with or without estrogen, while perfusates were continuously collected. LHRH in perfusates was measured by RIA. The results indicate that in both estrogen-primed and unprimed monkeys, NPY infusion into the S-ME elicited LHRH release in a dose-dependent manner (p < 0.01). Moreover, estrogen priming enhanced the responsiveness of LHRH release to NPY infusion: (1) the minimum NPY dose necessary to elicit a significant LHRH response was reduced, (2) the peak LHRH response to NPY at a dose of 10<sup>–6</sup> to 10<sup>–10</sup> M was increased, and (3) the total release of LHRH in response to NPY at doses of 10<sup>–6</sup> to 10<sup>–12</sup> M was increased. These results suggest that NPY stimulates LHRH release in the S-ME in the presence or absence of estrogen and that estrogen enhances the responsiveness of the LHRH neurosecretory system to NPY stimulation in the rhesus monkey.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 56
          : 6
          : 921-925
          Affiliations
          Wisconsin Regional Primate Research Center, University of Wisconsin-Madison, Madison, Wisc., USA
          Article
          126325 Neuroendocrinology 1992;56:921–925
          10.1159/000126325
          1369603
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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