Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

A Survey of Human Disease Gene Counterparts in the Drosophila Genome

Read this article at

ScienceOpenPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 31

      • Record: found
      • Abstract: found
      • Article: not found

      The genome sequence of Drosophila melanogaster.

       Yimin Wang,  M Zhan,  J Pacleb (2000)
      The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        A Drosophila model of Parkinson's disease.

        Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.
          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Comparative genomics of the eukaryotes.

          A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
            Bookmark

            Author and article information

            Affiliations
            [a ]Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
            [b ]Celera Genomics, Rockville, Maryland 20850
            [c ]National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894
            [d ]Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129
            Contributors
            Journal
            J Cell Biol
            The Journal of Cell Biology
            The Rockefeller University Press
            0021-9525
            1540-8140
            24 July 2000
            : 150
            : 2
            : 23-30
            2180233
            10908582
            0006015
            © 2000 The Rockefeller University Press
            Categories
            Analysis

            Cell biology

            Comments

            Comment on this article