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      The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis.

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          Abstract

          The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.

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          Author and article information

          Journal
          Semin. Cell Dev. Biol.
          Seminars in cell & developmental biology
          Elsevier BV
          1096-3634
          1084-9521
          May 2018
          : 77
          Affiliations
          [1 ] School of Life Sciences, University of Warwick, United Kingdom. Electronic address: mark.wall@warwick.ac.uk.
          [2 ] School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, United Kingdom. Electronic address: S.A.L.Correa@bradford.ac.uk.
          Article
          S1084-9521(17)30372-5
          10.1016/j.semcdb.2017.09.005
          28890421
          6afdc90e-e54a-4e07-b666-a6b862a4bb9e
          History

          Rectification,AMPA receptors,Adaptor protein 2,Arc/Arg3.1,Endocytosis

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