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      Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.

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          Abstract

          Increased platelet aggregation plays a pivotal role in the etiology of cardiovascular disease. Upon platelet aggregation, an increase in free cytoplasmic Ca(2+) results in the inhibition of soluble guanylyl cyclase (sGC) and adenylyl cyclase (AC), leading to a decrease in cyclic guaninosine-5'-monophosphate (cGMP) and cAMP, respectively. This leads to the activation of the glycoprotein IIb/IIIa (GPIIb/IIIa) fibrinogen receptor, resulting in platelet shape change. Aged garlic extract (AGE) decreases platelet aggregation; however, the mechanisms involved are not clearly defined.

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          Author and article information

          Journal
          J. Nutr.
          The Journal of nutrition
          American Society for Nutrition
          1541-6100
          0022-3166
          Feb 2016
          : 146
          : 2
          Affiliations
          [1 ] School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom k.rahman@ljmu.ac.uk.
          [2 ] School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
          Article
          jn.114.202408
          10.3945/jn.114.202408
          26764324
          6b010386-d6f7-424e-9eab-83810490b4a5
          History

          cAMP,fibrinogen,garlic,platelet aggregation,thrombosis,GPIIb/IIIa receptor

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