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      Blood Vessels and the Aging Kidney

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          Abstract

          Aging is associated with a degenerative effect on many organs including the kidney. Blood vessels play a key role in the progression of renal damage in aging, with reductions in glomerular filtration rate and renal blood flow. Therefore, there is considerable interest in the haemodynamic and molecular mechanisms that may be responsible for alterations in the vascular system in aging. In this review, we will describe the evidence that aging is accompanied by alterations in vascular tone and angiogenesis alongside renal damage. The contributions of mediators such as nitric oxide, angiotensin II and vascular endothelial growth factor will also be discussed.

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          Author and article information

          Journal
          NEE
          Nephron Exp Nephrol
          10.1159/issn.1660-2129
          Cardiorenal Medicine
          S. Karger AG
          1660-2129
          2005
          November 2005
          26 July 2005
          : 101
          : 3
          : e95-e99
          Affiliations
          aNephro-Urology Unit, Institute of Child Health, University College London, London, UK; bSection of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Fla., USA
          Article
          87146 Nephron Exp Nephrol 2005;101:e95–e99
          10.1159/000087146
          16043968
          © 2005 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 1, References: 39, Pages: 1
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/87146
          Categories
          Minireview

          Cardiovascular Medicine, Nephrology

          Angiogenesis, Aging, Blood vessels, Vascular tone

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