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      Blood Vessels and the Aging Kidney

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          Aging is associated with a degenerative effect on many organs including the kidney. Blood vessels play a key role in the progression of renal damage in aging, with reductions in glomerular filtration rate and renal blood flow. Therefore, there is considerable interest in the haemodynamic and molecular mechanisms that may be responsible for alterations in the vascular system in aging. In this review, we will describe the evidence that aging is accompanied by alterations in vascular tone and angiogenesis alongside renal damage. The contributions of mediators such as nitric oxide, angiotensin II and vascular endothelial growth factor will also be discussed.

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          Author and article information

          Nephron Exp Nephrol
          Cardiorenal Medicine
          S. Karger AG
          November 2005
          26 July 2005
          : 101
          : 3
          : e95-e99
          aNephro-Urology Unit, Institute of Child Health, University College London, London, UK; bSection of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Fla., USA
          87146 Nephron Exp Nephrol 2005;101:e95–e99
          © 2005 S. Karger AG, Basel

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          Page count
          Figures: 1, References: 39, Pages: 1
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/87146

          Cardiovascular Medicine, Nephrology

          Angiogenesis, Aging, Blood vessels, Vascular tone


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