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      An Autoradiographic and Pathological Study of Cellular Proliferation in Rabbit Arteries Correlated with an Increase in Arterial Pressure

      Journal of Vascular Research

      S. Karger AG

      Vascular muscle, Aortic constriction, Mitoses, Hypertension, Necrosis, 3H-Thymidine labeling

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          Following partial constriction of the abdominal aorta, the increase in arterial pressure in vessels proximal to the ligature at 3, 6, 14, 21 and 28 days was correlated with pathological changes and with proliferation of cells in the arterial wall measured by <sup>3</sup>H-thymidine labeling indices and mitotic counts. The time course of arterial pressure rise and vascular smooth muscle cell proliferation were similar. Patterns of proliferation of cells of the artery wall varied in distribution with time, the presence or absence of traumatic changes seen by light microscopy, and the histological structure of the vessel. Arteries not subject to hypertension did not differ from sham-operated animals.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 13
          : 1-2
          : 100-128
          Department of Pathology, School of Medicine, Center for Health Sciences, University of California, Los Angeles, Calif.
          158083 Blood Vessels 1976;13:100–128
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 29
          Research Paper


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