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      Evidence for the Conversion of Angiotensin I to Angiotensin II by the Coronary Microcirculation

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          Abstract

          Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (A<sub>I</sub>) to angiotensin II (A<sub>II</sub>). A<sub>I</sub> caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the A<sub>II</sub> antagonist (Sar<sup>1</sup>-Ala<sup>8</sup>) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert A<sub>I</sub> to A<sub>II</sub> in a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1979
          1979
          19 September 2008
          : 16
          : 5
          : 241-246
          Affiliations
          Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebr.
          Article
          158211 Blood Vessels 1979;16:241–246
          10.1159/000158211
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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