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      Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging

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          Most cited references28

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          Recent advances in twisted intramolecular charge transfer (TICT) fluorescence and related phenomena in materials chemistry

          Twisted intramolecular charge transfer (TICT) is an electron transfer process that occurs upon photoexcitation in molecules that usually consist of a donor and acceptor part linked by a single bond. Twisted intramolecular charge transfer (TICT) is an electron transfer process that occurs upon photoexcitation in molecules that usually consist of a donor and acceptor part linked by a single bond. Following intramolecular twisting, the TICT state returns to the ground state either through red-shifted emission or by nonradiative relaxation. The emission properties are potentially environment-dependent, which makes TICT-based fluorophores ideal sensors for solvents, (micro)viscosity, and chemical species. Recently, several TICT-based materials have been discovered to become fluorescent upon aggregation. Furthermore, various recent studies in organic optoelectronics, non-linear optics and solar energy conversions utilised the concept of TICT to modulate the electronic-state mixing and coupling on charge transfer states. This review presents a compact overview of the latest developments in TICT research, from a materials chemistry point of view.
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            The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping.

            Invisible NIR fluorescent light can provide high sensitivity, high-resolution, and real-time image-guidance during oncologic surgery, but imaging systems that are presently available do not display this invisible light in the context of surgical anatomy. The FLARE imaging system overcomes this major obstacle. Color video was acquired simultaneously, and in real-time, along with two independent channels of NIR fluorescence. Grayscale NIR fluorescence images were converted to visible "pseudo-colors" and overlaid onto the color video image. Yorkshire pigs weighing 35 kg (n = 5) were used for final preclinical validation of the imaging system. A six-patient pilot study was conducted in women undergoing sentinel lymph node (SLN) mapping for breast cancer. Subjects received (99m)Tc-sulfur colloid lymphoscintigraphy. In addition, 12.5 microg of indocyanine green (ICG) diluted in human serum albumin (HSA) was used as an NIR fluorescent lymphatic tracer. The FLARE system permitted facile positioning in the operating room. NIR light did not change the look of the surgical field. Simultaneous pan-lymphatic and SLN mapping was demonstrated in swine using clinically available NIR fluorophores and the dual NIR capabilities of the system. In the pilot clinical trial, a total of nine SLNs were identified by (99m)Tc- lymphoscintigraphy and nine SLNs were identified by NIR fluorescence, although results differed in two patients. No adverse events were encountered. We describe the successful clinical translation of a new NIR fluorescence imaging system for image-guided oncologic surgery.
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              Beyond the margins: real-time detection of cancer using targeted fluorophores

              Intraoperative fluorescence enables highly specific real-time detection of tumours at the time of surgery. In particular, near-infrared (NIR) fluorescence is a promising tool currently being tested in clinical settings. Zhang et al. discuss the latest developments in NIR fluorophores, cancer-targeting strategies, and detection instrumentation for intraoperative cancer detection, as well as the challenges associated with their effective application in clinical settings.
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                Author and article information

                Journal
                Advanced Materials
                Adv. Mater.
                Wiley
                09359648
                August 2018
                August 2018
                July 09 2018
                : 30
                : 34
                : 1802546
                Affiliations
                [1 ]Laboratory of Molecular Imaging and Nanomedicine; National Institute of Biomedical Imaging and Bioengineering (NIBIB); National Institutes of Health (NIH); Bethesda MD 20892 USA
                [2 ]State Key Laboratory of Precision Spectroscopy; School of Physics and Materials Science; East China Normal University; Shanghai 200062 China
                [3 ]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine; School of Public Health; Xiamen University; Xiamen 361102 China
                [4 ]Nirmidas Biotech; Palo Alto CA 94303 USA
                [5 ]Intuitive Surgical; Kifer Rd Sunnyvale CA 94086 USA
                Article
                10.1002/adma.201802546
                6b243b1c-fde8-489c-9010-686477921cc3
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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