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      Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization

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          Abstract

          Animal studies and preliminary results in humans suggest that lower extremity and myocardial ischemia can be attenuated by treatment with angiogenic cytokines. The resident population of endothelial cells that is competent to respond to an available level of angiogenic growth factors, however, may potentially limit the extent to which cytokine supplementation enhances tissue neovascularization. Accordingly, we transplanted human endothelial progenitor cells (hEPCs) to athymic nude mice with hindlimb ischemia. Blood flow recovery and capillary density in the ischemic hindlimb were markedly improved, and the rate of limb loss was significantly reduced. Ex vivo expanded hEPCs may thus have utility as a "supply-side" strategy for therapeutic neovascularization.

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          Author and article information

          Journal
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          0027-8424
          1091-6490
          March 28 2000
          March 28 2000
          : 97
          : 7
          : 3422-3427
          Article
          10.1073/pnas.97.7.3422
          16255
          10725398
          6b2ae11d-66f6-4aa1-be45-5027d41432dc
          © 2000
          History

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